This FASCINATING Molecule Originally Boosted Muscle & Endurance But Is Now Being Shown To Reverse Immune Aging?! Urolithin A With Dr. Anurag Singh

Ben Greenfield

Sep 4, 2025

Episode description

Anurag Singh is currently Chief Medical Officer at Timeline that develops next generation advanced nutritional and skincare products targeting improvements in mitochondrial and cellular health. With a M.D. in internal medicine and a Ph.D. in immunology, his experience includes work for top consumer health (Nestlé, Nestlé Health Science) and startups companies (Amazentis/Timeline).

He’s authored > 50 articles for top science journals, been awarded >20 patents and has designed and led > 50 randomized clinical trials. His research over the past decade across multiple clinical trials on the postbiotic Urolithin A (Mitopure) and its health benefits has led to the launch of multiple consumer products.

Full show notes: bengreenfieldlife.com/timelineimmunity

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Mindsip insights from this episode:

Pursue solutions to enhance muscle, immune, and cognitive health by 10 years

The next frontier in longevity may be finding a single solution that simultaneously improves muscle, immune, and cognitive health by 10 years, which is the goal of a Peter Diamandis X-Prize.

#longevity

#muscle

Boost mitochondria through exercise, creatine, and Urolithin A

You can boost mitochondria through biogenesis (via exercise), efficiency (via creatine or CoQ10), and mitophagy or cellular cleanup (via Urolithin A).

#mitochondria

#supplement

Juice 60 pomegranates for effective Urolithin A dose

To get a clinically effective 1000mg dose of Urolithin A from food, you would need to juice approximately 60 pomegranates.

Recharge immune cells with Urolithin A to combat cancer

Research shows Urolithin A recharges the mitochondria of critical immune cells, including Natural Killer (NK) cells and cytotoxic T-cells, which are crucial for fighting cancer.

#cancer

#urolithin

Utilize Urolithin A and Ozempic to enhance CAR-T cell therapy

A recent study screening 8,000 compounds found that only Urolithin A and a GLP-1 drug (like Ozempic) could recharge specialized CAR-T immune cells used in cancer therapy.

#cancer

#urolithin

Take 1 gram of Urolithin A for immune support

Clinical trials consistently show that a 1-gram dose of Urolithin A is needed to see significant effects on the immune system, such as lowering the whole-body inflammation marker C-reactive protein (CRP).

#immune-system

#urolithin

Prioritize immune health to combat aging triggers

A unique perspective is that immune aging is the central piece and primary trigger for many of the other hallmarks of aging, not just one of many equal factors.

#aging

#immune-system

Balance your immune system with urolithin A as a modulator

Urolithin A acts as an 'immune modulator,' meaning it can strengthen a weak, fatigued immune system while also reining in an overactive one to maintain balance.