This Gene controls Ergothioneine linked Mitochondrial Benefits

Physionic

Jul 3, 2024

Episode description

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References [Copy & Paste DOI into Search Engine]
[1] doi:10.1101/2024.04.10.588849

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#mitochondrialhealth

Episode description

Mindsip insights from this episode:

Utilize PGC1-alpha to enhance ergothioneine transporter production

The PGC1-alpha protein likely works by binding to other proteins, called transcription factors, allowing them to read the gene that creates the ergothioneine transporter.

#cells

Inhibit protein blockers to enhance ergothioneine transporter production

An alternative theory is that PGC1-alpha may stop proteins that normally inhibit the production of the ergothioneine transporter, thereby allowing it to be created.

#metabolism

Question real-world impact of regulatory gene increase on ergothioneine levels

A critical look at the data shows a massive 18-times increase in a regulatory gene led to only a 30% increase in ergothioneine, questioning the practical impact for humans.

#genetics

#study

Boost ergothioneine transport with exercise

New research shows that exercise first raises PGC1-alpha levels, which then increases the gene expression for the transporter that allows ergothioneine into your cells.