TMG: Should it be Exploding in Popularity?

Physionic

Apr 30, 2025

Episode description

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*HEALTH AUTONOMY [COURSE]*
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Created with Biorender

0:00 - Introduction
0:45 - Mechanisms of TMG
1:16 - Disagreeing Data
1:43 - Fat Loss: Bad Data vs Good Data
5:40 - Muscle Performance
7:18 - Sources of TMG
7:38 - A Missing Link of TMG
8:10 - Main Points

Next Video Referenced: https://www.youtube.com/watch?v=Z-x076J2tfE&t=268s

References
[Study 442] Ashtary-Larky D, Bagheri R, Tinsley GM, et al. Betaine supplementation fails to improve body composition: a systematic review and meta-analysis. Br J Nutr. 2022;128(5):975–988. doi:10.1017/S0007114521004062

Funding/Conflicts: No Funding / No direct Conflicts of Interest

[Study 443] Gao X, Zhang H, Guo X, Li K, Li S, Li D. Effect of betaine on reducing body fat—A systematic review and meta-analysis of randomized controlled trials. Nutrients. 2019;11(10):2480. doi:10.3390/nu11102480

Funding/Conflicts: Public Funding [National Natural Science Foundation of China, the Key Scientific Research Projects in Shandong Province, the Natural Science Foundation of Shandong Province, and the Chinese Nutrition Society Nutrition Research Foundation–DSM Research Fund] / No direct Conflicts of Interest

[Study 444] Zawieja E, Machek S, Zanchi NE, Cholewa J, Woźniewicz M. Effects of chronic betaine supplementation on exercise performance: systematic review and meta-analysis. J Sports Sci. Published online November 8, 2024. doi:10.1080/02640414.2024.2423578

Funding/Conflicts: No Funding / No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#tmg #betaine

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:45 - Mechanisms of TMG
1:16 - Disagreeing Data
1:43 - Fat Loss: Bad Data vs Good Data
5:40 - Muscle Performance
7:18 - Sources of TMG
7:38 - A Missing Link of TMG
8:10 - Main Points

Next Video Referenced: https://www.youtube.com/watch?v=Z-x076J2tfE&t=268s

References
[Study 442] Ashtary-Larky D, Bagheri R, Tinsley GM, et al. Betaine supplementation fails to improve body composition: a systematic review and meta-analysis. Br J Nutr. 2022;128(5):975–988. doi:10.1017/S0007114521004062

Funding/Conflicts: No Funding / No direct Conflicts of Interest

[Study 443] Gao X, Zhang H, Guo X, Li K, Li S, Li D. Effect of betaine on reducing body fat—A systematic review and meta-analysis of randomized controlled trials. Nutrients. 2019;11(10):2480. doi:10.3390/nu11102480

Funding/Conflicts: Public Funding [National Natural Science Foundation of China, the Key Scientific Research Projects in Shandong Province, the Natural Science Foundation of Shandong Province, and the Chinese Nutrition Society Nutrition Research Foundation–DSM Research Fund] / No direct Conflicts of Interest

[Study 444] Zawieja E, Machek S, Zanchi NE, Cholewa J, Woźniewicz M. Effects of chronic betaine supplementation on exercise performance: systematic review and meta-analysis. J Sports Sci. Published online November 8, 2024. doi:10.1080/02640414.2024.2423578

Funding/Conflicts: No Funding / No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#tmg #betaine

Mindsip insights from this episode:

Incorporate wheat and spinach for optimal TMG intake

Standardized to 100 grams, good dietary sources of TMG include wheat and spinach, with lesser amounts in turkey and shrimp.

Avoid TMG supplementation for effective fat loss

Based on the most appropriate statistical analysis of current data, TMG supplementation is more likely ineffective for fat loss.

Clarify conflicting TMG studies on fat loss effects

Different conclusions on TMG's fat loss effects come from how statistical analyses weigh the same underlying studies, not from different data.

Exercise before taking TMG for effective fat loss and muscle performance

If you do not exercise, taking TMG for fat loss or muscle performance is likely a waste of money.

Pair TMG with exercise for optimal effectiveness

TMG is likely most effective, if at all, when it is paired with exercise, especially resistance training.

Boost lower body strength with TMG supplementation

TMG supplementation appears to be effective at increasing muscle strength, specifically in the lower body, even if not in the upper body.

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