Top 5 Dopamine Boosting Biohacks for Superhuman Energy
Dave Asprey
Aug 5, 2025
Mindsip insights from this episode:
Beware emotional blunting from daily Ashwagandha use
Daily use of Ashwagandha may cause emotional blunting by desensitizing the 5HT1A serotonin receptor, similar to the effects of SSRIs.
Utilize inositol tris pyrophosphate to enhance oxygen release for endurance
Inositol tris pyrophosphate (ITPP) is a compound that may act like EPO by increasing the amount of oxygen released by red blood cells by up to 35%.
Supplement with progesterone, pregnenolone, and DHEA for stress management
Women over 35 should consider supplementing with progesterone, pregnenolone, and DHEA to replace declining levels of these 'counter-stress' hormones.
Limit collagen intake to avoid inflammation from excess oxalate
Consuming more than 20 grams of collagen per day can be harmful as the excess hydroxyproline converts into oxalate, which causes inflammation.
Manipulate neurotransmitters for optimal mental performance
The concept of 'cosmetic neurology' involves intentionally manipulating your neurotransmitters with specific compounds to create the ideal mental state for any given task.
Microdose Cyproheptadine for 'super sleep' benefits
Microdosing the antihistamine Cyproheptadine can induce a 'super sleep' by powerfully lowering cortisol, adrenaline, and serotonin.
Embrace morning cortisol spike for immune and cognitive health
Constantly suppressing cortisol is a mistake, as a morning cortisol spike is beneficial for immune function, cognitive function, and setting your circadian rhythm.
Achieve social dominance with optimal neurotransmitter balance
The state of complete social dominance and productivity is achieved with high dopamine, high GABA, moderately high acetylcholine, and very low serotonin.
Boost dopamine synthesis with Bromantane's genetic enhancement
The Russian medication Bromantane increases the genetic expression of the tyrosine hydroxylase enzyme, which boosts dopamine synthesis from precursors like tyrosine.
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