Uncovering the Roots of Exhaustion—and How to Feel Like Yourself Again

Mark Hyman

Dec 1, 2025

Episode description

Many people experience a deep, lingering fatigue that isn’t fixed by a full night’s sleep, and it often stems from real imbalances inside the body. When mitochondria—the tiny engines that power our cells—are stressed by poor diet, toxins, infections, or lack of rest, the whole system can slow down. Ongoing stress can also disrupt the adrenal system, leaving some people feeling wired and anxious while others feel drained from morning to night. The encouraging news is that steady habits like nourishing whole foods, balanced blood sugar, restorative sleep, and gentle movement can help the body find its rhythm again. With the right support, energy often returns, and a sense of hope does, too.

In this episode, I dive into, along with Dr. Izabella Wentz and Dr. Elizabeth Boham, the real roots of chronic fatigue, showing how stress, lifestyle, and hidden imbalances drain our energy—and how practical, nourishing habits can help restore it.

Izabella Wentz is an internationally acclaimed thyroid specialist and a licensed pharmacist who has dedicated her career to addressing the root causes of autoimmune thyroid disease after being diagnosed with Hashimoto’s thyroiditis in 2009. She is the author of three books on Hashimoto’s: Hashimoto’s Thyroiditis Lifestyle Interventions for Finding and Treating the Root Cause, Hashimoto’s Food Pharmacology, and Hashimoto’s Protocol, which became a #1 New York Times bestseller.

Dr. Elizabeth Boham is Board Certified in Family Medicine from Albany Medical School, and she is an Institute for Functional Medicine Certified Practitioner and the Medical Director of The UltraWellness Center. Dr. Boham lectures on a variety of topics, including Women’s Health and Breast Cancer Prevention, insulin resistance, heart health, weight control and allergies. She is on the faculty for the Institute for Functional Medicine.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:
How to Reclaim Your Energy and Overcome Chronic Fatigue

Tired And Wired: How To Heal Adrenal Fatigue

Getting To The Root Causes Of Why We Are All Tired



(0:00) Introduction to the episode with Dr. Izabella Wentz

(1:34) Overview of health ingredients and functional medicine

(2:41) Factors damaging mitochondria and lab testing for fatigue

(6:27) Dietary changes and time-restricted eating benefits

(9:10) Food as medicine and the impact of common drugs on energy

(11:43) Exercise and

Episode description

Many people experience a deep, lingering fatigue that isn’t fixed by a full night’s sleep, and it often stems from real imbalances inside the body. When mitochondria—the tiny engines that power our cells—are stressed by poor diet, toxins, infections, or lack of rest, the whole system can slow down. Ongoing stress can also disrupt the adrenal system, leaving some people feeling wired and anxious while others feel drained from morning to night. The encouraging news is that steady habits like nourishing whole foods, balanced blood sugar, restorative sleep, and gentle movement can help the body find its rhythm again. With the right support, energy often returns, and a sense of hope does, too.

In this episode, I dive into, along with Dr. Izabella Wentz and Dr. Elizabeth Boham, the real roots of chronic fatigue, showing how stress, lifestyle, and hidden imbalances drain our energy—and how practical, nourishing habits can help restore it.

Izabella Wentz is an internationally acclaimed thyroid specialist and a licensed pharmacist who has dedicated her career to addressing the root causes of autoimmune thyroid disease after being diagnosed with Hashimoto’s thyroiditis in 2009. She is the author of three books on Hashimoto’s: Hashimoto’s Thyroiditis Lifestyle Interventions for Finding and Treating the Root Cause, Hashimoto’s Food Pharmacology, and Hashimoto’s Protocol, which became a #1 New York Times bestseller.

Dr. Elizabeth Boham is Board Certified in Family Medicine from Albany Medical School, and she is an Institute for Functional Medicine Certified Practitioner and the Medical Director of The UltraWellness Center. Dr. Boham lectures on a variety of topics, including Women’s Health and Breast Cancer Prevention, insulin resistance, heart health, weight control and allergies. She is on the faculty for the Institute for Functional Medicine.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:
How to Reclaim Your Energy and Overcome Chronic Fatigue

Tired And Wired: How To Heal Adrenal Fatigue

Getting To The Root Causes Of Why We Are All Tired



(0:00) Introduction to the episode with Dr. Izabella Wentz

(1:34) Overview of health ingredients and functional medicine

(2:41) Factors damaging mitochondria and lab testing for fatigue

(6:27) Dietary changes and time-restricted eating benefits

(9:10) Food as medicine and the impact of common drugs on energy

(11:43) Exercise and

Mindsip insights from this episode:

Support mitochondrial energy with key nutrients

Specific nutrients that directly support mitochondrial energy production include Acetyl-L-carnitine, alpha-lipoic acid, coenzyme Q10, and N-acetylcysteine (NAC).

Choose low glycemic options to reduce breakfast stress

Even a seemingly healthy breakfast like oatmeal can cause a flood of stress hormones like adrenaline and cortisol due to its high glycemic load.

Avoid exercise and fasting during severe adrenal dysfunction

If you are in a state of severe adrenal dysfunction or 'flatlined' adrenals, common health advice like exercising or fasting can actually make you feel worse.

Take Urolithin A supplement for mitochondrial cleanup

Urolithin A, a compound your gut should make from pomegranates but often can't, can be taken as a supplement to help remove and recycle damaged mitochondria.

Release exerkines through exercise to boost mitochondrial health

Exercise releases signaling molecules called 'exerkines,' which positively influence your biology by helping to create new mitochondria.

Utilize red light therapy to enhance energy and healing

Red light therapy works by having a mitochondrial enzyme absorb specific wavelengths of light, which enhances energy production and upregulates genes for healing.

Recognize four stages of adrenal dysfunction to combat burnout

Adrenal dysfunction progresses through four stages: from a high-energy 'wired' state, to a cortisol 'roller coaster,' to a 'reverse curve' with morning fatigue, and finally a 'flatlined' state of chronic exhaustion.

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© Mindsip 2025 – Made with ❤ in Vilnius