WE DID IT! I’m in tears…
Brad Stanfield
Oct 20, 2024
Mindsip insights from this episode:
Utilize rapamycin to extend lifespan by 20%
In animal studies, the molecule rapamycin has been shown to make both male and female subjects live 20% longer.
Block mTOR to enhance muscle strength through cellular cleanup
The central hypothesis is that blocking the muscle growth enzyme mTOR with rapamycin could paradoxically make muscles stronger by first clearing out cellular junk.
Manage mTOR activation to preserve muscle health with age
As we age, our muscles overactivate the growth enzyme mTOR, but this doesn't build new protein and instead leads to an accumulation of old, damaged parts.
Utilize rapamycin weekly to enhance muscle autophagy
By taking rapamycin once a week to temporarily turn off mTOR, muscles get a chance to clean out old, damaged proteins through a process called autophagy.
Utilize open-source trial protocols to accelerate research
The clinical trial protocol is published open access, allowing other research groups to copy the work and significantly speed up future studies.
Cycle rapamycin with exercise for cellular cleanup and muscle rebuilding
The proposed strategy is to take rapamycin on one day for cellular cleanup, and then on other days, use exercise to switch mTOR back on and rebuild new, healthier muscle tissue.
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