When Oreos outperform Statins in lowering Cholesterol, ft. Dr. Nick Norwitz and Dave Feldman

Physionic

Mar 9, 2024

Episode description

Nick's Channel: https://youtu.be/yiq67wpUhIs?si=AAercNmT4OX6fk_z
Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT

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References (Copy & Paste DOI into Search)
[1] doi:10.3390/metabo14010073
[2] DOI:https://doi.org/10.1093/cdn/nzab144
[3] DOI: 10.3390/metabo12050460

0:00 - Introduction of Study
3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman
8:31 - Dr. Norwitz details the Oreo Study
31:52 - Problems with Science Communication
1:11:40 - Concluding Remarks

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#lmhr #leanmasshyperresponder #heartdisease

Episode description

Mindsip insights from this episode:

Refill liver glycogen with carbs to regulate LDL levels

The high LDL in lean, low-carb individuals is thought to be driven by the liver sending out fat for energy; adding carbs (even from Oreos) refills liver glycogen and stops this process.

#LDL

#liver

Consume Oreos to significantly lower LDL cholesterol

In a case study, eating 12 Oreo cookies daily for 16 days lowered LDL cholesterol by 71%, outperforming a 32.5% reduction from a high-intensity statin.

#LDL

#statin

Investigate high LDL cholesterol on Mediterranean-style keto diet

One researcher experienced his LDL cholesterol skyrocketing to over 500 on a very low saturated fat, Mediterranean-style ketogenic diet consisting mostly of fish and olive oil.

#keto

#LDL

Confront uncomfortable questions to advance scientific understanding

The point of a provocative experiment like the Oreo study is not to give health advice, but to force the scientific community to grapple with uncomfortable questions and reconcile seemingly contradictory results.

#research

Reevaluate saturated fat's role in LDL spikes

The massive LDL spike in lean mass hyper-responders is not primarily caused by saturated fat, as one researcher's highest LDL of 545 occurred on a diet with a 1-to-5.7 ratio of saturated to unsaturated fat.

#LDL

#saturated-fat

Vilify six-pack over butter for high LDL levels

On a low-carb diet, having a low BMI is a stronger predictor of skyrocketing LDL than eating butter, leading to the phrase: 'If you want to vilify something for high LDL, vilify the six-pack.'.

#BMI

#LDL

Manipulate lipid system for rapid cholesterol changes

Contrary to the belief that cholesterol levels are stable, the lipid system is extremely dynamic and can be manipulated to change dramatically in a matter of days.