Why Are Hackers Microdosing “Sex Drugs” Now?

Dave Asprey

Mar 3, 2026

Episode description

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice.

Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise.

This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology.

You'll Learn:

Why precision medicine outperforms population-based health strategies for human performance
How to layer genomics, transcriptomics, and proteomics into one complete biological picture
Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine
How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits
The real story on metformin, peptides, and which supplements actually move the needle
How AI can help you understand your own biology and act on it faster
Why biohacking precision beats random stacking every time

Thank you to our sponsors!

• Igniton | Head over to Igniton.com and use code DAVE for an exclusive

Mindsip insights from this episode:

Monitor MMP9 to combat musculoskeletal pain and aging

The protein MMP9, which is often unmeasured, is a key driver of deep musculoskeletal pain and rapid aging.

#aging

#pain

Utilize microdosing for bioregulatory benefits in longevity

Low doses of certain pharmaceuticals can provide bioregulatory benefits by modulating specific pathways, unlike high doses which can shut down receptors.

#longevity

#microdosing

Incorporate EGCG from green tea to influence inflammation

Taking EGCG, a compound found in green tea, is a simple way to positively influence the NLRP3 inflammasome, a key driver of systemic inflammation.

#inflammation

#supplement

Beware metformin's impact on mitochondrial function and exercise benefits

Despite its popularity as a longevity drug, metformin can blunt mitochondrial function and reduce the physiological benefits of exercise.

#metformin

#mitochondria

Embrace multi-omic approach for precision medicine

Precision medicine is moving beyond just genetics (genomics) to include layers like RNA (transcriptomics) and proteins (proteomics) for a complete picture of your health.

#genetics

#research

Utilize vagal stimulation to reduce inflammation

Vagal nerve stimulation can directly reduce systemic inflammation and fibrosis by influencing the NLRP3 inflammasome.

#inflammation

#vagus-nerve

Reevaluate Fatty 15 as potential omega-3 alternative

While the supplement Fatty 15 (C15) is interesting, it may not be the 'next Omega-3' as the body can synthesize it from other dietary sources like cultured butter.

#C15

#supplement

Microdose Cialis nightly to enhance brain health and prevent Alzheimer's

Taking a small, 5mg dose of Cialis nightly is suggested as a longevity practice to improve vascular tone and potentially prevent Alzheimer's.

#Alzheimer's

#microdosing

Prioritize mitochondrial health before biohacking interventions

The order of biohacking interventions is critical, as using a technology like red light therapy on someone with poor mitochondria without first addressing it can be ineffective.