Why Being Normal Weight Might Be a Death Sentence...

Physionic

Jul 24, 2025

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
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*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
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Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:53 - Relative Fat Mass
2:50 - T-O-F-I
4:18 - How can a person be overweight and healthier than you?
6:35 - Fat Depots & What to Do
9:35 - Main Points

References
[Study 491] Woolcott, O. O., Samarasundera, E., & Heath, A. K. Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality. ​ Scientific Reports, 2024.

Funding/Conflicts: Public [The Third Division Tumxuk City Science and Technology Innovation Talent Program (Grant KY2025RC03); China Postdoctoral Science Foundation (Grant 2024M761177)] / No direct Conflicts of Interest

[Study 492] Agrawal S, Klarqvist MDR, Diamant N, et al. ​ BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases. ​ Nat Commun. 2023;14:35704. doi:10.1038/s41467-022-35704-5 ​

Funding/Conflicts: Public [National Heart, Lung, and Blood Institute (NHLBI, NIH); National Institute on Aging (NIA, NIH)] // No direct Conflicts of Interest

[Study 493] Karpe, F., & Pinnick, K. E. (2014). ​ Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes. ​ Nature Reviews Endocrinology. ​ Advance online publication.

Funding/Conflicts: Public [National Institute on Aging (NIA, NIH)] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:53 - Relative Fat Mass
2:50 - T-O-F-I
4:18 - How can a person be overweight and healthier than you?
6:35 - Fat Depots & What to Do
9:35 - Main Points

References
[Study 491] Woolcott, O. O., Samarasundera, E., & Heath, A. K. Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality. ​ Scientific Reports, 2024.

Funding/Conflicts: Public [The Third Division Tumxuk City Science and Technology Innovation Talent Program (Grant KY2025RC03); China Postdoctoral Science Foundation (Grant 2024M761177)] / No direct Conflicts of Interest

[Study 492] Agrawal S, Klarqvist MDR, Diamant N, et al. ​ BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases. ​ Nat Commun. 2023;14:35704. doi:10.1038/s41467-022-35704-5 ​

Funding/Conflicts: Public [National Heart, Lung, and Blood Institute (NHLBI, NIH); National Institute on Aging (NIA, NIH)] // No direct Conflicts of Interest

[Study 493] Karpe, F., & Pinnick, K. E. (2014). ​ Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes. ​ Nature Reviews Endocrinology. ​ Advance online publication.

Funding/Conflicts: Public [National Institute on Aging (NIA, NIH)] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Target visceral fat with caloric restriction

A calorically restricted diet leads to preferential reductions in the most harmful type of fat, which is the visceral fat around your organs.

Understand unique gene signatures of fat depots

Different fat depots in your body, like visceral and gluteofemoral, have unique gene signatures and may even originate from different stem cells during development.

Recognize gluteofemoral fat as protective against diabetes and heart disease

Storing fat in the gluteofemoral region, around the thighs and butt, is linked to a reduced risk of diabetes and heart disease.

Identify TOFI condition: thin outside, fat inside

You might be 'TOFI' (Thin Outside, Fat Inside) if your BMI is under 25 but your waist is over 88cm for women or 102cm for men.

Prioritize fat location over total weight for better health

The location of your body fat is more important for your health than your total weight, with visceral fat being harmful and gluteofemoral (butt and thigh) fat being protective.

Combat skinny fat by combining fat loss with resistance training

If you are 'skinny fat,' you should combine fat loss with resistance training to replace harmful visceral fat with metabolically demanding muscle.

Understand fat types to manage visceral and gluteofemoral fat effectively

Visceral fat has a faster turnover that dumps fat into organs under stress, while protective gluteofemoral fat acts as a buffer by safely storing it.

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