Why do we develop plaque in our arteries, but not our veins?

Physionic

Apr 29, 2024

Episode description

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Created with Biorender
Original Video: https://youtu.be/kvvUB-BUMNs?si=Cf4zwrCSf6o8rJee

References (Copy & Paste DOI into Search Engine)
[1] doi:10.1159/000174019
[2] doi:10.1053/pcad.2002.123471
[3] doi.org/10.1093/eurheartj/ehz962
[4] doi:10.3389/fphar.2020.613780
[5] doi:10.3389/fcvm.2022.925923
[6] doi:10.1097/MOL.0000000000000330
[7] doi:10.1097/00041433-200210000-00001
[8] doi:10.1016/s0925-4439(01)00102-8
[9] doi:10.1016/s0174-173x(86)80033-4
[10] doi:10.1093/ajh/hpy083
[11] doi:10.1002/9780470513385.ch13

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#heartdiseaseawereness #heartdiseaseprevention #heartdisease

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H


Created with Biorender
Original Video: https://youtu.be/kvvUB-BUMNs?si=Cf4zwrCSf6o8rJee

References (Copy & Paste DOI into Search Engine)
[1] doi:10.1159/000174019
[2] doi:10.1053/pcad.2002.123471
[3] doi.org/10.1093/eurheartj/ehz962
[4] doi:10.3389/fphar.2020.613780
[5] doi:10.3389/fcvm.2022.925923
[6] doi:10.1097/MOL.0000000000000330
[7] doi:10.1097/00041433-200210000-00001
[8] doi:10.1016/s0925-4439(01)00102-8
[9] doi:10.1016/s0174-173x(86)80033-4
[10] doi:10.1093/ajh/hpy083
[11] doi:10.1002/9780470513385.ch13

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#heartdiseaseawereness #heartdiseaseprevention #heartdisease

Mindsip insights from this episode:

Recognize environmental impact on grafted veins to prevent atherosclerosis

When a vein is surgically grafted into the arterial blood supply, it can develop atherosclerosis, suggesting the environment, not just the vein itself, is key.

Understand why veins resist plaque buildup unlike arteries

Despite being exposed to the same amount of LDL cholesterol, veins do not develop the plaque buildup (atherosclerosis) that is seen in arteries.

Manage blood pressure to prevent plaque buildup in arteries

The higher blood pressure in arteries can drastically alter the gene expression of blood vessel cells, causing them to produce more of the proteins that lead to plaque buildup.

Differentiate proteoglycan types to understand LDL attraction in arteries

The specific type of proteoglycan chains (GAGs) most prevalent in arteries has a much greater chemical attraction to LDL than the types found in veins.

Understand LDL retention in arteries due to proteoglycans

Arteries contain much higher amounts of molecules called proteoglycans, which act to retain LDL particles, compared to veins.

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