Why Metabolic Disease strikes at Every Weight

Physionic

Mar 4, 2024

Episode description

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Created with Biorender

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References (Copy & Paste DOI into Search)
[1] [Study 249] doi:10.1111/joim.13214
[2] [Study 250] doi:10.1038/nm0410-400

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#diabetesawareness #reversingdiabetes

Episode description

Mindsip insights from this episode:

Reveal hidden pancreatic cells to understand diabetes

A newer theory suggests that in diabetes, insulin-producing pancreatic cells don't die but instead 'de-differentiate,' reverting to a stem-cell-like state and hiding their function.

#diabetes

#stem-cell

Understand personal fat threshold to explain diabetes resistance in overweight individuals

Some severely overweight people may not develop diabetes easily because their liver remains relatively fat-free, indicating a higher personal fat threshold.

#diabetes

#liver

Target liver fat to prevent diabetes risk

It's not overall body fat but specifically the accumulation of fat in the liver that can set someone on the path to diabetes, even at a lower body weight.

#diabetes

#liver

Understand personal fat threshold to prevent type 2 diabetes

The development of type 2 diabetes may depend on an individual's 'personal fat threshold' rather than their overall weight.

#diabetes

#obesity

Reverse type 2 diabetes by uncovering hidden pancreatic cells

The idea that pancreatic cells are merely 'hiding' rather than being permanently destroyed lends hope that type 2 diabetes can be reversed.

#diabetes

#regeneration

Block insulin response by understanding fat molecule effects

Fat molecules like diacylglycerols and ceramides activate a protein called PKC, which directly inhibits the cell's internal machinery from responding to insulin.