Biohacking News Weekly Update

Dave Asprey

24 oct 2025

Episode description

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.



This episode covers:



• Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm



• The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html



• FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter



• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events

Episode description

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.



This episode covers:



• Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm



• The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html



• FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter



• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events

Mindsip insights from this episode:

Activate autophagy with dietary bacteria from fermented foods

Specific dietary bacteria that carry double-stranded RNA, found in fermented foods like kimchi and kefir, can activate autophagy and signal your cells to repair themselves.

Ensure new supplements undergo FDA vetting for safety

The FDA is closing the 'generally recognized as safe' loophole, meaning every new supplement compound will now need to be vetted before it hits the market.

Leverage biometric data to create your medical avatar

Your biometric data could soon feed into a 'medical avatar,' a living digital twin of your body that predicts health problems before you even feel symptoms.

Leverage gene variant to reverse cardiac aging and promote new blood vessel growth

A gene variant found in people who live past 100, lav bpifb4, has been shown to reverse signs of cardiac aging and grow new blood vessels in lab animals.

Choose kava for social relaxation without sleep disruption

Tru Kava offers the relaxing social benefits of alcohol by increasing GABA, dopamine, and serotonin, without destroying your sleep score or metabolic health.

Take 2000iu of vitamin D daily to slow DNA aging

A new five-year study found that taking 2000iu of vitamin D daily slowed telomere shortening by an amount equivalent to being a couple of years biologically younger.

Train recovery actively with HeartMath HRV exercises

Instead of only tracking recovery, you can actively train it with a device like HeartMath, which uses HRV exercises to shift your nervous system into a state of coherence.

Maintain 25-hydroxy D levels between 60 and 80 for optimal health

For optimal cellular benefits from vitamin D, your 25-hydroxy D blood level should be in the 60 to 80 range.

Leverage beef organ supplements for energy and hormonal balance

Women are driving an 8,000% increase in beef organ supplement sales, reporting significant shifts in energy, hormonal balance, and skin clarity.

Reduce cardiovascular death with daily cocoa extract

The massive Cosmos trial found that older adults taking a daily cocoa extract rich in flavanols saw a 27% reduction in cardiovascular deaths.

Leverage spirulina for collagen support and DNA protection

New studies show spirulina supports collagen production and protects DNA from oxidative stress, leading to a 'green stacking' trend with chlorella.

Protect your bio-data with new privacy legislation

A new Senate bill aims to extend HIPAA-level privacy protections to data from wearables and wellness apps, recognizing that your biology should belong to you.

Utilize hydrogen water to energize cells and reduce oxidative stress

Hydrogen is the only molecule small enough to get deep inside your cells, mitochondria, and even your DNA to fuel energy and reduce oxidative stress.

Utilize AI stethoscope to detect early health issues

The FDA-cleared Keku 2.0 AI digital stethoscope allows home users to detect subtle changes in heart and lung sounds weeks before symptoms might appear.

Upgrade mattress for enhanced sleep quality with EMF protection

The Essentia mattress offers an upgrade with enhanced EMF protection built into its organic foam to improve REM and deep sleep cycles.

Implement sauna and ice pack protocol to detox microplastics

Biohacker Bryan Johnson published lab-verified results showing an 85% reduction in semen microplastics using daily 200-degree dry saunas followed by ice packs on the groin.

Accelerate cellular experiments with AI model from DeepMind and Yale

Google DeepMind and Yale launched an open-source AI model called 'Cell to Sentence Scale' that allows scientists to simulate cellular experiments in days instead of years.

Utilize first blood test to diagnose chronic fatigue syndrome

Scientists have developed the first accurate blood test for Chronic Fatigue Syndrome (ME/CFS) by measuring specific DNA methylation and microRNA patterns.

Activate healing with Vibrant Blue Oil's parasympathetic blend

Vibrant Blue Oil's parasympathetic blend is an essential oil applied behind the ears to activate the nervous system's healing mode by switching off the stress response.

Reduce aggression by supplementing with omega-3s

A new meta-analysis of randomized controlled trials found that omega-3 supplementation can reduce both reactive and proactive aggression by up to 28%.

Rethink long-term melatonin use to reduce heart failure risk

Long-term nightly melatonin use, a hormone and not a vitamin, is linked to nearly doubled heart failure risk and can disrupt other key hormones affecting testosterone and fertility.

Boost immune cells with urolithin A from Mitopure

A human trial in Nature Aging showed that Timeline Nutrition's Mitopure (Urolithin A) measurably increased youthful CD8 T cells and natural killer cells in four weeks.

Boost mitochondrial protein COX7RP to enhance lifespan and metabolic health

A new mouse study found that boosting a mitochondrial protein called COX7RP increased lifespan by about 6.5% and improved metabolic health.

Utilize non-invasive heart scanner to detect blockages safely

Mayo Clinic is testing a non-invasive device called Cardiac that reads the magnetic fields around your heart to spot blockages without radiation or contact.

Utilize psilocybin sessions to enhance blood sugar control

A single guided psilocybin session was shown to dramatically improve blood sugar control, with one person's average glucose dropping by 8% and their HbA1c dropping from 4.7 to 4.4.

Utilize screen protector to convert harmful blue light into beneficial red light

The Bodyguardz Red Light Converter is a screen protector that converts harmful blue light into beneficial red light to protect skin collagen and improve sleep.

Beware misleading supplement labels amid relaxed FDA rules

The FDA may loosen warning label rules, making supplement claims seem more legitimate precisely when oversight is getting lighter.

Understand sauna benefits: chemicals vs. microplastics

While sweating in a sauna can remove plastic-related chemicals like BPA, it has not been shown to remove the intact microplastic particles themselves.

Embrace whole foods to align with new US dietary guidelines

The new 2025-2030 US dietary guidelines finally call out ultra-processed foods as a problem and emphasize whole foods, aligning federal policy with longevity principles.

Reintroduce whole milk in schools for healthier kids

The Whole Milk for Healthy Kids Act was signed, allowing whole milk back in US schools and signaling an institutional shift away from low-fat ideology.

Utilize multi-wavelength light therapy for recovery and energy

The EMR Tech Krypton UV line is a light therapy system that combines red, near-infrared, UVA, and UVB wavelengths for recovery and energy.

Design personalized combinations for effective longevity interventions

The future of longevity is less about a single magic pill and more about intelligently designed, timed, and personalized combinations of interventions that target multiple systems.

Leverage AI for personalized health management

The new ChatGPT Health is a dedicated AI experience that lets users upload medical records and connect wellness app data to get summaries and interpret labs.

Extend lifespan with oxytocin and a5i combination in mice

In a recent study, a combination of oxytocin and a compound called a5i extended the remaining lifespan of old, frail male mice by about 73%.

Test tirzepatide to slow biological aging in clinical trial

A new clinical trial is explicitly testing whether the drug tirzepatide can slow biological aging by using DNA methylation aging clocks as a primary endpoint.

Train immunity with dead bacteria from kefir

Your immune system responds to microbial information from heat-inactivated bacteria, like those in some kefir, providing immune training without live probiotics.

Optimize selenium intake with half a Brazil nut every other day

Selenium has a U-shaped mortality curve, and for a safe dose, you might consider just a half bite of a Brazil nut every other day.

Gain control and reduce decision fatigue with time-restricted eating

The main win from time-restricted eating is not a metabolic miracle but gaining control by reducing decision fatigue and mindless snacking.

Upgrade cellular energy with Mitopure for longevity

Mitopure, a supplement containing a clinically validated dose of urolithin A, is recommended to upgrade cellular energy and support longevity.

Address colon cancer risk in elite endurance athletes

Even elite endurance athletes are at risk for early-onset colon cancer, which may be linked to microbiome disruption from a toxin called colibactin in infancy.

Supplement magnesium to activate vitamin D levels

Magnesium deficiency is often the bottleneck preventing vitamin D activation, and supplementing it can help normalize vitamin D levels.

Choose 5:2 fasting for better metabolic health

The 5:2 intermittent fasting method may provide superior improvements in fasting glucose, triglycerides, and insulin sensitivity compared to standard daily calorie restriction.

Utilize copper peptides to enhance collagen synthesis beyond tretinoin

Topical copper peptides have been found to significantly increase collagen synthesis, even outperforming the popular retinoid tretinoin over a short time frame.

Utilize organ age to predict disease and mortality risk

Knowing the biological age of individual organs predicts disease and mortality risk far more accurately than relying on a single, blended biological age score.

Cycle skincare with retinoids and copper peptides for optimal results

You should cycle your skincare by using aggressive remodeling products like retinoids when your skin is resilient and repairing products like copper peptides when it's inflamed.

Train your nervous system's resilience with HRV exercises

Instead of just tracking recovery, you can actively train your nervous system's resilience using a device like HeartMath that guides you through HRV exercises.

Discover organ-specific aging with Systemage testing

Your body doesn't age uniformly, and a test like Systemage from Generation Lab can show you the specific biological age of your brain, immune system, and other organs.

Make longevity drugs accessible for all through new pricing agreements

New drug pricing agreements could make powerful longevity medications like GLP1s and SGLT2 inhibitors accessible beyond wealthy biohackers.

Leverage theobromine in cocoa to slow biological aging

A specific compound in cocoa called theobromine, not just dark chocolate in general, is linked to slower biological aging according to DNA methylation clocks.

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad