Biohacking News Weekly Update

Dave Asprey

24 oct 2025

Episode description

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.



This episode covers:



• Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm



• The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html



• FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter



• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events

Episode description

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.



This episode covers:



• Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm



• The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html



• FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter



• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events

Mindsip insights from this episode:

Activate autophagy with dietary bacteria from fermented foods

Specific dietary bacteria that carry double-stranded RNA, found in fermented foods like kimchi and kefir, can activate autophagy and signal your cells to repair themselves.

Ensure new supplements undergo FDA vetting for safety

The FDA is closing the 'generally recognized as safe' loophole, meaning every new supplement compound will now need to be vetted before it hits the market.

Leverage biometric data to create your medical avatar

Your biometric data could soon feed into a 'medical avatar,' a living digital twin of your body that predicts health problems before you even feel symptoms.

Leverage gene variant to reverse cardiac aging and promote new blood vessel growth

A gene variant found in people who live past 100, lav bpifb4, has been shown to reverse signs of cardiac aging and grow new blood vessels in lab animals.

Choose kava for social relaxation without sleep disruption

Tru Kava offers the relaxing social benefits of alcohol by increasing GABA, dopamine, and serotonin, without destroying your sleep score or metabolic health.

Take 2000iu of vitamin D daily to slow DNA aging

A new five-year study found that taking 2000iu of vitamin D daily slowed telomere shortening by an amount equivalent to being a couple of years biologically younger.

Train recovery actively with HeartMath HRV exercises

Instead of only tracking recovery, you can actively train it with a device like HeartMath, which uses HRV exercises to shift your nervous system into a state of coherence.

Maintain 25-hydroxy D levels between 60 and 80 for optimal health

For optimal cellular benefits from vitamin D, your 25-hydroxy D blood level should be in the 60 to 80 range.

Leverage beef organ supplements for energy and hormonal balance

Women are driving an 8,000% increase in beef organ supplement sales, reporting significant shifts in energy, hormonal balance, and skin clarity.

Reduce cardiovascular death with daily cocoa extract

The massive Cosmos trial found that older adults taking a daily cocoa extract rich in flavanols saw a 27% reduction in cardiovascular deaths.

Leverage spirulina for collagen support and DNA protection

New studies show spirulina supports collagen production and protects DNA from oxidative stress, leading to a 'green stacking' trend with chlorella.

Protect your bio-data with new privacy legislation

A new Senate bill aims to extend HIPAA-level privacy protections to data from wearables and wellness apps, recognizing that your biology should belong to you.

Utilize hydrogen water to energize cells and reduce oxidative stress

Hydrogen is the only molecule small enough to get deep inside your cells, mitochondria, and even your DNA to fuel energy and reduce oxidative stress.

Utilize AI stethoscope to detect early health issues

The FDA-cleared Keku 2.0 AI digital stethoscope allows home users to detect subtle changes in heart and lung sounds weeks before symptoms might appear.

Upgrade mattress for enhanced sleep quality with EMF protection

The Essentia mattress offers an upgrade with enhanced EMF protection built into its organic foam to improve REM and deep sleep cycles.

Implement sauna and ice pack protocol to detox microplastics

Biohacker Bryan Johnson published lab-verified results showing an 85% reduction in semen microplastics using daily 200-degree dry saunas followed by ice packs on the groin.

Accelerate cellular experiments with AI model from DeepMind and Yale

Google DeepMind and Yale launched an open-source AI model called 'Cell to Sentence Scale' that allows scientists to simulate cellular experiments in days instead of years.

Utilize first blood test to diagnose chronic fatigue syndrome

Scientists have developed the first accurate blood test for Chronic Fatigue Syndrome (ME/CFS) by measuring specific DNA methylation and microRNA patterns.

Activate healing with Vibrant Blue Oil's parasympathetic blend

Vibrant Blue Oil's parasympathetic blend is an essential oil applied behind the ears to activate the nervous system's healing mode by switching off the stress response.

Reduce aggression by supplementing with omega-3s

A new meta-analysis of randomized controlled trials found that omega-3 supplementation can reduce both reactive and proactive aggression by up to 28%.

Rethink long-term melatonin use to reduce heart failure risk

Long-term nightly melatonin use, a hormone and not a vitamin, is linked to nearly doubled heart failure risk and can disrupt other key hormones affecting testosterone and fertility.

Boost immune cells with urolithin A from Mitopure

A human trial in Nature Aging showed that Timeline Nutrition's Mitopure (Urolithin A) measurably increased youthful CD8 T cells and natural killer cells in four weeks.

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad