Creatine, Sleep Trackers, and AI Doctors | Bryan Johnson Podcast #3

Bryan Johnson

Apr 18, 2025

Episode description

🥦 Order my Blueprint Stack: https://blueprint.bryanjohnson.com/collections/all-products
📩 Subscribe for my latest protocols: https://dontdie.bryanjohnson.com/

UNSW Creatine study: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatine-makes-no-difference-to-muscle-gains-trial-finds
Andrej Karpathy’s sleep tracker study: https://karpathy.bearblog.dev/finding-the-best-sleep-tracker/

Hosts
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson

Let’s be friends:
Twitter: https://x.com/bryan_johnson
Instagram: https://www.instagram.com/bryanjohnson_
TikTok: https://www.tiktok.com/@_bryan_johnson_

Project Blueprint and Don’t Die celebrate that we, humanity, are evolving into something new. Join me on this journey.

Chapters
0:00 - Intro
0:41 - 1: Welcome to the Don't Die podcast
2:52 - 2: Dr. Mike’s experience as an ER physician
7:32 - 3: Difference between America and New Zealand ER
9:38 - 4: Dr. Mike on using ChatGPT
13:00 - 5: New study on creatine effectiveness
18:40 - 6: How much creatine to take per day
24:33 - 7: Body awareness
29:33 - 8: Blueprint protocol’s limit in slowing aging
30:57 - 9: Andrej Karpathy’s sleep monitor study
36:10 - Conclusion

Episode description

🥦 Order my Blueprint Stack: https://blueprint.bryanjohnson.com/collections/all-products
📩 Subscribe for my latest protocols: https://dontdie.bryanjohnson.com/

UNSW Creatine study: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatine-makes-no-difference-to-muscle-gains-trial-finds
Andrej Karpathy’s sleep tracker study: https://karpathy.bearblog.dev/finding-the-best-sleep-tracker/

Hosts
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson

Let’s be friends:
Twitter: https://x.com/bryan_johnson
Instagram: https://www.instagram.com/bryanjohnson_
TikTok: https://www.tiktok.com/@_bryan_johnson_

Project Blueprint and Don’t Die celebrate that we, humanity, are evolving into something new. Join me on this journey.

Chapters
0:00 - Intro
0:41 - 1: Welcome to the Don't Die podcast
2:52 - 2: Dr. Mike’s experience as an ER physician
7:32 - 3: Difference between America and New Zealand ER
9:38 - 4: Dr. Mike on using ChatGPT
13:00 - 5: New study on creatine effectiveness
18:40 - 6: How much creatine to take per day
24:33 - 7: Body awareness
29:33 - 8: Blueprint protocol’s limit in slowing aging
30:57 - 9: Andrej Karpathy’s sleep monitor study
36:10 - Conclusion

Mindsip insights from this episode:

Prioritize health to reduce preventable ER visits

An ER doctor estimates that over 80% of emergency room visits are for preventable chronic diseases that result from a culture that doesn't value health.

Calculate creatine dose based on body weight for precision

A more precise daily creatine dose is 0.1 grams per kilogram of body weight, rather than a generic 5-gram scoop for everyone.

Increase creatine intake to enhance brain performance

For cognitive benefits, such as offsetting poor sleep or for mild cognitive impairment, studies have used much higher creatine doses of 10-20 grams per day.

Continue creatine for cognitive and metabolic benefits

A recent study questioning creatine's muscle-building effects is not a reason to stop taking it, as its benefits for cognition, bone health, and metabolic health are well-established.

Choose Oura or Whoop for optimal sleep tracking and performance correlation

In an N-of-1 experiment by AI researcher Andrej Karpathy, Oura and Whoop were found to be the top-tier sleep trackers for correlating sleep quality with daily performance.

Balance body awareness with tolerance for unhealthy choices

As you get healthier and more body-aware, you may become less tolerant of unhealthy foods and activities that other people seem to handle fine.

Recognize hidden brain decline before symptoms appear

Your brain can compensate for impairment from things like alcohol long before you behaviorally show symptoms, meaning you are often more unhealthy than you are aware.

Utilize LLMs to advocate for your care in the ER

An ER doctor suggests inputting your symptoms into an LLM like ChatGPT to understand the proper care protocol and advocate for yourself in a broken system.

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© Mindsip 2025 – Made with ❤ in Vilnius

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© Mindsip 2025 – Made with ❤ in Vilnius