Do Sugar Spikes cause Heart Disease? There’s more to this Story…
Physionic
Jul 22, 2024
Episode description
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References [Copy & Paste DOI into Search]
[1] doi:10.1111/j.1467-789X.2012.01011.x
[2] doi:10.1161/01.cir.0000034509.14906.ae
[3] doi:10.1152/jappl.1985.58.3.785
[4] doi:10.1161/01.CIR.0000134501.57864.66
[5] doi:10.4158/EP.12.S1.25
[6] doi:10.1177/193229680700100513
[7] doi:10.2337/db08-0063
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#glucosespikes #glucosemonitoring #glucosecontrol
Mindsip insights from this episode:
Maintain blood glucose below 140 mg/dL for optimal health
Research on healthy, non-insulin resistant individuals shows they spend less than 1% of their day with blood glucose above the 140 mg/dL level.
Infuse antioxidants with glucose to eliminate inflammation spikes
In one study, when antioxidants were infused along with glucose, the inflammatory effect of the glucose spike was virtually eliminated, highlighting the importance of food context.
Address underlying health issues behind glucose spikes
If your glucose spikes regularly extend beyond 180-200 mg/dL, it likely indicates an underlying health issue like insulin resistance that should be the primary focus over the spikes themselves.
Reassess glucose spike concerns beyond 140 mg/dL
We still do not have a scientifically established cutoff for what is considered a concerning glucose spike, and the harmful level may be well above the commonly cited 140 mg/dL.
Manage glucose spikes to prevent RAGE pathway activation
Glucose spikes can activate a cellular receptor called RAGE (Receptor for Advanced Glycation End products), which triggers a pro-inflammatory protein cascade in your cells.
Clarify long-term glucose studies to improve heart disease understanding
Many long-term studies linking glucose to heart disease are based on a two-hour oral glucose tolerance test, which is not the same as measuring the peak of a meal-induced spike on a continuous glucose monitor.
Link post-meal glucose spikes to cardiovascular health improvement
A study showed that the drug repaglinide, which specifically flattens post-meal glucose spikes, led to an improvement in atherosclerosis, suggesting a link between spikes and cardiovascular health.
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