Exclusive Dr. Hyman+ Ask a Doctor: Gut Health and Alzheimer’s, Genetic Risk of Disease, And More
Mark Hyman
Jan 30, 2024
Mindsip insights from this episode:
Understand APOE4 gene as risk factor, not a certainty for dementia
The APOE4 gene is considered a 'low penetrance' gene, meaning it increases dementia risk but does not guarantee you will get the disease.
Manage hormones to influence Lipoprotein(a) levels
Hormonal shifts like menopause or hypothyroidism can elevate Lipoprotein(a), and hormone replacement therapy can sometimes lower it by 20-30%.
Lower Lp(a) levels with PCSK9 inhibitors
A newer class of cholesterol medications called PCSK9 inhibitors can lower Lipoprotein(a) levels by 20-30%.
Beware statins: they may increase Lipoprotein(a) levels
Statin medications like Lipitor and Crestor do not lower Lipoprotein(a) and may, in fact, slightly increase it.
Get tested for lipoprotein(a) to establish baseline risk
Because Lipoprotein(a) levels are largely genetic and stable, it is often considered a once-in-a-lifetime test to establish your baseline risk.
Aim for higher omega-3 index of 8-12% if APOE4 positive
For individuals with the APOE4 gene, the target for the Omega-3 Index should be higher than average, aiming for 8-12% instead of the standard 8%.
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