How Dogs Are Going to Make You Live Longer: Rapamycin & Longevity – Matt Kaeberlein

Dave Asprey

Mar 19, 2024

Episode description

How can we make our furry best friends live longer, healthier lives?

A true pioneer in this field, Dr. Matt Kaeberlein, is here to unpack this important subject while highlighting the crossover between human and canine longevity. You read that right; this episode isn't just for dog lovers—it's a deep dive into longevity for humans, too.

Dr. Matt Kaeberlein, who's the CEO of Optispan and a key figure in the Dog Aging Project, brings a wealth of knowledge from his distinguished career in aging and healthspan research. He's an Affiliate Professor at the University of Washington and a notable figure in gerontology, recognized by organizations like the American Association for the Advancement of Science and the Gerontological Society of America.

Matt's work is groundbreaking, demonstrated in over 250 scientific papers on aging, numerous prestigious awards, and he's even a Fellow of several aging associations. He's on a mission to unlock the secrets of aging, not just in humans, but in our four-legged companions as well.

We explore the accuracy of measuring age with telomeres versus epigenetics and get into the nitty-gritty of diet's impact on longevity for both dogs and humans, reminding us it's not just about living longer, but living well.

Matt explains the impressive trial results on rapamycin for reducing age-related inflammation, a breakthrough that's not just exciting for us but also for our pets. Finally, we touch on how AI is revolutionizing our approach to understanding and extending our healthspan.

For those who want to get more involved, check out dogagingproject.org. It's not every day you meet someone who's made such significant strides in understanding aging across species. So whether you're a pet parent or just passionate about extending your own health span, this episode is for you.

(00:01:31) Dogs Are the Bridge Between Lab Studies & Human Longevity

(00:11:09) Exploring the Impact of Diet on Longevity

(00:18:50) How Our Unique Biology Impacts Aging

(00:26:33) Exploring How Size & Diet Impact Health Across Species

(00:37:55) Fighting Age-Related Inflammation with Rapamycin

(00:56:40) AI Interventions for Longevity Testing

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Resources

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books

Learn More: dogaging

Mindsip insights from this episode:

Release 10 million stem cells for natural repair with Stemregen

A product called Stemregen is mentioned as the world's first stem cell enhancer, claiming to release 10 million of your own stem cells from your bone marrow to aid in natural repair.

#stem-cell

#supplement

Question the reliability of consumer aging clocks

While useful for research, the utility of consumer aging clocks is questionable due to a lack of data on their precision and reproducibility.

#aging

#research

Leverage companion dogs to study environmental aging factors

Companion dogs are a powerful research bridge between lab animals and humans because they share our environment, allowing for the study of environmental factors in aging.

#environment

#longevity

Initiate longevity interventions in middle age for health benefits

Scientific literature now shows that you can start longevity interventions in middle age and still achieve significant positive effects on both healthspan and lifespan.

#healthspan

#longevity

Recognize smaller individuals for longer lifespans within species

While larger species live longer than smaller ones, within a single species like dogs or humans, smaller individuals tend to live longer than larger ones.

#longevity

Prioritize high protein and resistance training for aging well

Contrary to some longevity advice, a higher amount of dietary protein combined with resistance training is a very good strategy for maintaining muscle and bone density as you age.

#aging

#protein

Utilize rapamycin to alleviate frozen shoulder pain

The speaker shares his personal experience of taking 6mg of rapamycin per week, which resolved his severe frozen shoulder pain and restored 95% of his range of motion in 10 weeks.

#pain

#rapamycin

Broaden research focus beyond hallmarks of aging

The popular 'hallmarks of aging' framework may have inadvertently narrowed scientific focus, making it difficult to get funding for research outside of these established areas.