Hyaluronic Acid Reversed Wrinkles by 18% in Human Study

Brad Stanfield

Apr 13, 2025

Episode description

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Here are the links to the research papers referenced in the video:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522662/
https://pmc.ncbi.nlm.nih.gov/articles/PMC10082573/
https://pubs.acs.org/doi/10.1021/jf8017029
https://pmc.ncbi.nlm.nih.gov/articles/PMC3512263/
https://www.sciencedirect.com/science/article/abs/pii/S0144861723003454
https://pmc.ncbi.nlm.nih.gov/articles/PMC4110621/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308347/
https://pubmed.ncbi.nlm.nih.gov/34933842/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661223/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730721/
https://pubmed.ncbi.nlm.nih.gov/24894153/
https://vkm.no/download/18.6e7666b2187eb18c9e45e014/1683710709924/Hyaluronsyre%20i%20kosttilskudd.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299688/

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

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Episode description

Mindsip insights from this episode:

Ensure gut bacteria for effective hyaluronic acid absorption

Hyaluronic acid can only be absorbed after gut bacteria break it down into smaller pieces; in a study, mice with no gut bacteria absorbed none of the supplement.

#hyaluronic-acid

#microbiome

Avoid high molecular weight hyaluronic acid for better value

New research from 2023 shows that expensive, high molecular weight hyaluronic acid is broken down in the stomach, so there's no reason to specifically buy that form.

#hyaluronic-acid

#supplement

Recommend sodium hyaluronate at 200 milligrams for enhanced stability

The speaker recommends sodium hyaluronate at a 200 milligram dose, citing its enhanced stability, solubility, and its common use in clinical trials.

#supplement

Utilize chemical molds to objectively measure wrinkles

To get an objective measure of wrinkles, researchers apply a chemical to make a mold of the skin, which is then peeled off and scanned.

#testing

#wrinkles

Leverage hyaluronic acid metabolites for skin benefits

The skin benefits from oral hyaluronic acid are not from the molecule reaching the skin directly, but from the indirect effects of its metabolites created after digestion.

#hyaluronic-acid

#skin

Understand that HA supplements don't accelerate cancer growth

While lab studies on cancer cells raised concerns, studies in mice with existing cancer found that oral hyaluronic acid supplements did not accelerate tumor growth.