If you’re taking Fish Oil… Your Arteries are Quickly Changing.

Physionic

Jul 14, 2025

Episode description

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*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
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Created with Biorender

0:00 - Introduction
1:24 - What happens?
3:34 - Should we trust this?
6:02 - Immune Migration from the Arteries
9:49 - How does this fit in the broader literature?
10:20 - Super duper important point..
10:40 - Main Points

References
[Study 484] Feuchtner G, Langer C, Barbieri F, et al. The effect of omega-3 fatty acids on coronary atherosclerosis quantified by coronary computed tomography angiography. Clin Nutr. 2021;40(3):1123-1129. doi:10.1016/j.clnu.2020.07.016

Funding/Conflicts: None / No direct Conflicts of Interest

[Study 485] Thies F, Garry JM, Yaqoob P, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003;361(9356):477-485. doi:10.1016/S0140-6736(03)12468-3

Funding/Conflicts: Public Funding [This research was supported by a grant to RFG, PCC, and CPS from the Food Standards Agency (grant number ANO238); JMCG held a postgraduate studentship from the Ministry of Agriculture, Fisheries, and Food; KR was supported by the Faculty of Medicine, Chiang Mai University, Thailand, and by the Royal Thai Government] // No direct Conflicts of Interest

[Study 486] Motoyama S, Nagahara Y, Sarai M, et al. Effect of Omega-3 Fatty Acids on Coronary Plaque Morphology: A Serial Computed Tomography Angiography Study. Circ J. 2022;86(5):831–842. doi:10.1253/circj.CJ-21-0615

Funding/Conflicts: No Funding / 3 Researchers are Editors for Circulation Journal

[Study 487] Zhang C, Xie Y, Zhou J, et al. Effects of Omega-3 Fatty Acids Intake on Lipid Metabolism and Plaque Volume in Patients With Coronary Heart Disease: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials. Food Sci Nutr. 2025;13(6):e70372. Published 2025 Jun 2. doi:10.1002/fsn3.70372

Funding/Conflicts: Public Funding [Sichuan Science and Technology Program: provincial government funding (public); Luzhou Municipal People’s Government – Southwest Medical University strategic cooperation: municipal government funding (public); Hejiang People’s Hospital – Southwest Medical University strategic cooperation: public hospital/university collaboration (public/non-profit); Xuyong People’s Hospital – Southwest Medical University strategic cooperation: public hospital/university collaboration (public/non-profit); Gulin County People’s Hospital – Affiliated Hospital of Southwest Medical University: public hospital/university collaboration (public/non-profit); China International Medical Foundation (project 2022-N-01-33): charitable foundation (non-profit) // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#omega3 #fishoilbenefits #hearthealth

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:24 - What happens?
3:34 - Should we trust this?
6:02 - Immune Migration from the Arteries
9:49 - How does this fit in the broader literature?
10:20 - Super duper important point..
10:40 - Main Points

References
[Study 484] Feuchtner G, Langer C, Barbieri F, et al. The effect of omega-3 fatty acids on coronary atherosclerosis quantified by coronary computed tomography angiography. Clin Nutr. 2021;40(3):1123-1129. doi:10.1016/j.clnu.2020.07.016

Funding/Conflicts: None / No direct Conflicts of Interest

[Study 485] Thies F, Garry JM, Yaqoob P, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003;361(9356):477-485. doi:10.1016/S0140-6736(03)12468-3

Funding/Conflicts: Public Funding [This research was supported by a grant to RFG, PCC, and CPS from the Food Standards Agency (grant number ANO238); JMCG held a postgraduate studentship from the Ministry of Agriculture, Fisheries, and Food; KR was supported by the Faculty of Medicine, Chiang Mai University, Thailand, and by the Royal Thai Government] // No direct Conflicts of Interest

[Study 486] Motoyama S, Nagahara Y, Sarai M, et al. Effect of Omega-3 Fatty Acids on Coronary Plaque Morphology: A Serial Computed Tomography Angiography Study. Circ J. 2022;86(5):831–842. doi:10.1253/circj.CJ-21-0615

Funding/Conflicts: No Funding / 3 Researchers are Editors for Circulation Journal

[Study 487] Zhang C, Xie Y, Zhou J, et al. Effects of Omega-3 Fatty Acids Intake on Lipid Metabolism and Plaque Volume in Patients With Coronary Heart Disease: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials. Food Sci Nutr. 2025;13(6):e70372. Published 2025 Jun 2. doi:10.1002/fsn3.70372

Funding/Conflicts: Public Funding [Sichuan Science and Technology Program: provincial government funding (public); Luzhou Municipal People’s Government – Southwest Medical University strategic cooperation: municipal government funding (public); Hejiang People’s Hospital – Southwest Medical University strategic cooperation: public hospital/university collaboration (public/non-profit); Xuyong People’s Hospital – Southwest Medical University strategic cooperation: public hospital/university collaboration (public/non-profit); Gulin County People’s Hospital – Affiliated Hospital of Southwest Medical University: public hospital/university collaboration (public/non-profit); China International Medical Foundation (project 2022-N-01-33): charitable foundation (non-profit) // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#omega3 #fishoilbenefits #hearthealth

Mindsip insights from this episode:

Consume omega-3s to stabilize arterial plaque composition

Consuming omega-3s is associated with changing arterial plaque to be more fibrous and calcified, which is a more stable and favorable composition.

Transform arterial plaque composition with omega-3 supplementation in five weeks

A randomized controlled trial showed that omega-3 supplementation can change the composition of arterial plaque in an average of only five weeks.

Stabilize plaque with omega-3s to reduce rupture risk

Omega-3s help stabilize plaque by reducing the number of inflammatory immune cells (macrophages) within it, which are known to increase rupture risk.

Remodel plaque with omega-3s for cardiovascular health

Evidence suggests one of the main cardiovascular benefits of omega-3s is their ability to remodel existing plaque to be less inflamed and more stable.

Enrich arterial plaque with omega-3s for better heart health

When you consume more omega-3s, the fats themselves become enriched within your arterial plaque, directly influencing its composition.

Recognize immune cells in arterial plaque for better heart health

The plaque in your arteries is not just fat and cholesterol; it also contains immune cells like macrophages and T-cells.

Distinguish between dangerous and stable arterial plaque

Soft, non-calcified plaque is especially dangerous because it can rupture, whereas calcified or fibrotic plaque is considered more stable and less risky.

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