
Mangoes: Protecting against Neurodegenerative Disease… with a Twist.
Physionic
Sep 13, 2025
Mindsip insights from this episode:
Utilize mango molecule magnafarin to combat brain aging
A molecule found in mangoes, called magnafarin, reduces neuroinflammation and cellular senescence in the brain's immune cells.
Acknowledge small cognitive boost from magnafarin trials
Human trials on magnafarin show a cognitive boosting benefit, but the effect size is quite small and the studies are mostly short-term.
Utilize magnafarin from mangoes to combat Alzheimer's plaques
In cell studies, magnafarin significantly reduces the inflammation caused by the buildup of plaques associated with diseases like Alzheimer's.
Question industry bias in magnafarin research findings
All of the human studies on magnafarin that the speaker could find were industry-associated, suggesting a potential for bias in the results.
Enjoy mangoes as an effortless health boost
The speaker concludes that the effect is not big enough to go out of your way for mangoes, but they are an easy win if you already like them.
Exercise caution with high doses of mango leaves
Despite their potency, one should be cautious with high doses from mango leaves as they have not been properly vetted in long-term trials.
Utilize mango leaves for higher magnafarin concentration
Mango leaves and peel contain significantly more magnafarin than the fruit, with leaves having anywhere from 5 to 50 times the concentration.
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