Massive New Study shows Niacin and NAD+ cause Heart Disease?? Is this true? [Study 282]
Physionic
Feb 26, 2024
Mindsip insights from this episode:
Monitor niacin byproducts to assess heart risk
A study found that two niacin breakdown products, 2Py and 4Py, are associated with a higher risk of major adverse cardiovascular events, independent of other risk factors.
Consider study limitations due to pre-existing heart disease in subjects
The people included in the study most likely already had some form of heart disease, potentially limiting the findings' applicability to the general population.
Identify genetic deficiency to assess cardiovascular risk
The increased cardiovascular risk may only apply to the minority of people with a deficient ACSMD enzyme, as three-quarters of study participants did not show elevated risk.
Identify 4Py as key factor in inflammation
Experiments suggest that the metabolite 4Py is the real problematic culprit causing inflammation, while 2Py may just be a passive bystander.
Investigate 4Py metabolite's role in inflammation through VCAM1 expression
The metabolite 4Py was shown to cause inflammation by increasing the expression of a protein called VCAM1, which makes immune cells stick to blood vessel walls.
Identify gene mutation linked to harmful metabolite levels
A specific gene, ACSMD, and a single mutation within it are tightly linked to higher levels of the potentially harmful 2Py and 4Py metabolites.
Dismiss concerns about niacin and cardiovascular disease
Despite the study's findings, the speaker concludes they are not worried about niacin causing cardiovascular disease, believing the researchers made a mistake in their interpretation.
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