Navigating bone health: early life influences and advanced strategies for improvement and injury prevention (#214 rebroadcast)

Peter Attia

Jul 7, 2025

Episode description

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In this episode from July 2022, Peter dives deep into the topic of bone health and explains why this is an important topic for everyone, from children to the elderly. He begins with an overview of bone mineral density, how it’s measured, how it changes over the course of life, and the variability between sexes largely due to changes in estrogen levels. From there he provides insights into ways that one can improve bone health, from exercise to nutrition supplements to drugs. Additionally, Peter discusses what happens when one may be forced to be sedentary (e.g., bedrest) and how you can work to minimize the damage during these periods.

While this original episode is an AMA, it is available in full to all listeners as a special rebroadcast.

We discuss:

Overview of bone health topics to be discussed [2:30];
Bones 101: bone function, structure, and more [6:15];
Bone mineral density (BMD), minerals in bone, role of osteoblasts and osteoclasts, and more [9:30];
The consequences of poor bone health [14:30];
The devastating nature of hip fractures: morbidity and mortality data [18:00];
Where fractures tend to occur in the body [23:45];
Defining osteopenia and osteoporosis [25:30];
Measuring BMD with DEXA and how to interpret scores [28:00];
Variability in BMD between sexes [35:15];
When should people have their first bone mineral density scan? [37:45];
How BMD changes throughout the life and how it differs between men and women [40:15];
How changes in estrogen levels (e.g., menopause) impact bone health [45:15];
Why HRT is not considered a standard of care for postmenopausal bone loss [49:00];
Factors determining who may be at higher risk of poor bone health [52:00];
Common drugs that can negatively impact BMD [55:45];
How children can optimize bone health and lay the foundation for the future [59:30];
Types of physical activity that can positively impact bone health [1:03:30];
How weight loss can negatively impact bone health and how exercise can counteract those effects [1:12:15];
Nutrition and supplements for bone health [1:16:00];
Pharmaceutical drugs prescribed

Episode description

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

While this original episode is an AMA, it is available in full to all listeners as a special rebroadcast.

We discuss:

Overview of bone health topics to be discussed [2:30];
Bones 101: bone function, structure, and more [6:15];
Bone mineral density (BMD), minerals in bone, role of osteoblasts and osteoclasts, and more [9:30];
The consequences of poor bone health [14:30];
The devastating nature of hip fractures: morbidity and mortality data [18:00];
Where fractures tend to occur in the body [23:45];
Defining osteopenia and osteoporosis [25:30];
Measuring BMD with DEXA and how to interpret scores [28:00];
Variability in BMD between sexes [35:15];
When should people have their first bone mineral density scan? [37:45];
How BMD changes throughout the life and how it differs between men and women [40:15];
How changes in estrogen levels (e.g., menopause) impact bone health [45:15];
Why HRT is not considered a standard of care for postmenopausal bone loss [49:00];
Factors determining who may be at higher risk of poor bone health [52:00];
Common drugs that can negatively impact BMD [55:45];
How children can optimize bone health and lay the foundation for the future [59:30];
Types of physical activity that can positively impact bone health [1:03:30];
How weight loss can negatively impact bone health and how exercise can counteract those effects [1:12:15];
Nutrition and supplements for bone health [1:16:00];
Pharmaceutical drugs prescribed

Mindsip insights from this episode:

Prioritize powerlifting to enhance bone mineral density

Powerlifting is more effective than regular strength training for maintaining bone mineral density, and both are superior to aerobic exercises like running or swimming.

#bones

#strength

Avoid smoking before 16 to protect bone density

Smoking before the age of 16 has a far more negative and lasting impact on bone density later in life compared to starting after 16, even if you quit.

#bones

#smoking

Initiate bone screening with DEXA scan in your 30s

Contrary to standard guidelines, it's recommended that women get a baseline DEXA scan in their 30s to understand their bone health trajectory well before menopause begins.

#bones

#DEXA

Ensure DEXA scan includes segmental analysis for accurate bone health assessment

When getting a DEXA scan for bone health, you must confirm the facility provides segmental analysis for the left hip, right hip, and lumbar spine, not just a whole-body score.

#bones

#DEXA

Recognize hip fracture's greater mortality risk than smoking

A hip fracture increases the risk of death within one year by 178%, a greater mortality risk than that associated with smoking.

#bones

#mortality

Maximize bone mass potential before age 20

Failing to reach your full genetic potential for bone mass by age 20 sets you on a permanently lower trajectory for the rest of your life.

#aging

#bones

Combine diet and exercise to protect bone density during weight loss

Losing weight through caloric restriction alone tends to decrease bone mineral density, but combining diet with significant exercise can offset this loss.

#bones

#exercise

Incorporate weight-bearing exercises to enhance bone density

Low weight-bearing activities like walking, swimming, and cycling do not significantly improve bone mineral density because they don't apply enough force to the muscles and bones.

#bones

#exercise

Peter Attia

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