Nutrition Alone isn’t Enough - Add This.

Physionic

Apr 18, 2025

Episode description

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Created with Biorender

0:00 - Introduction
1:09 - Study Design
1:45 - Results
3:13 - What is unique about this Study?
6:44 - Additional nuances
7:28 - Main Points

Reference
[Study 438] Beals JW, Kayser BD, Smith GI, et al. Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes. Nat Metab. 2023;5(7):1221-1235. doi:10.1038/s42255-023-00829-4

Funding/Conflicts: Mixed Funding (Public/Non-Profit) [National Institute of Health; Pershing Square Foundation and the Longer Life Foundation] // Potential Conflicts of Interest [Samuel Klein (S.K.), the corresponding author, serves on scientific advisory boards for Altimmune and Merck.]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:09 - Study Design
1:45 - Results
3:13 - What is unique about this Study?
6:44 - Additional nuances
7:28 - Main Points

Reference
[Study 438] Beals JW, Kayser BD, Smith GI, et al. Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes. Nat Metab. 2023;5(7):1221-1235. doi:10.1038/s42255-023-00829-4

Funding/Conflicts: Mixed Funding (Public/Non-Profit) [National Institute of Health; Pershing Square Foundation and the Longer Life Foundation] // Potential Conflicts of Interest [Samuel Klein (S.K.), the corresponding author, serves on scientific advisory boards for Altimmune and Merck.]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Leverage exercise to enhance insulin sensitivity on high-carb diet

The study demonstrated exercise's powerful effect on insulin sensitivity while participants were on a Pritikin-style, very high-carbohydrate diet.

Incorporate exercise for insulin sensitivity benefits beyond weight loss

Adding exercise to a diet provides significant insulin sensitivity benefits even when it doesn't lead to greater weight or fat loss compared to dieting alone.

Focus on insulin clearance, not secretion, for better health outcomes

In the study, the pancreas released the same amount of insulin in both diet and diet-plus-exercise groups, indicating the benefit came from increased insulin clearance, not reduced secretion.

Enhance insulin clearance through regular exercise

Exercise improves insulin sensitivity not just by making cells more receptive, but by increasing the rate at which the liver and kidneys clear insulin from the blood.

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