This Incredibly Popular Supplement DAMAGES Your Blood Vessels

Brad Stanfield

Apr 30, 2025

Episode description

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Here are the links to the research papers referenced in the video:
https://www.nature.com/articles/s41413-024-00346-4
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/486688
https://www.bmj.com/content/351/bmj.h4580
https://www.bmj.com/content/341/bmj.c3691.full
https://pubmed.ncbi.nlm.nih.gov/34244740/
https://www.bmj.com/content/346/bmj.f228
https://heart.bmj.com/content/98/12/920
https://www.ahajournals.org/doi/10.1161/jaha.116.003815
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1568523
https://www.jacc.org/doi/10.1016/j.jcmg.2020.06.030
https://pubmed.ncbi.nlm.nih.gov/34670754/
https://pubmed.ncbi.nlm.nih.gov/33964850/
https://ods.od.nih.gov/factsheets/iron-HealthProfessional/
https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007176.pub2/full
https://www.bocsci.com/resources/vitamin-e-tocopherols-and-tocotrienols-and-their-derivatives.html
https://pmc.ncbi.nlm.nih.gov/articles/PMC1790869/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4169010/
https://jamanetwork.com/journals/jama/fullarticle/2793446
https://pubmed.ncbi.nlm.nih.gov/24011076/
https://pubmed.ncbi.nlm.nih.gov/12939617/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3598361/
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011919.pub2/full
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30476-7
https://pmc.ncbi.nlm.nih.gov/articles/PMC3810808/
https://pubmed.ncbi.nlm.nih.gov/27754722/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9938530/

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Mindsip insights from this episode:

Obtain calcium from food to reduce artery calcification risk

Getting calcium from food is the safest approach, as high dietary intake is linked to a 27% lower risk of artery calcification.

#artery

#calcium

Limit iron supplements to protect zinc levels and organs

Taking too much iron from supplements can reduce zinc levels and cause organ damage, so it's best to get it from your diet unless prescribed by a doctor.

#iron

#supplement

Reconsider vitamin E supplementation to avoid increased mortality

A Cochrane analysis of almost 300,000 people suggests that supplementing with vitamin E, a popular antioxidant, might actually increase mortality.

#mortality

#supplement

Avoid high doses of vitamin A supplements to protect health

Similar to vitamin E, high doses of vitamin A supplements are also associated with increased mortality and can weaken bones and damage the liver.

#liver

#supplement

Reevaluate resveratrol claims after lab error revelation

The initial excitement for resveratrol was based on a study claiming it extended yeast lifespan by 70%, which was later revealed to be a lab error.

#longevity

#research

Avoid resveratrol to maximize exercise benefits

Resveratrol supplementation was found to reduce the positive effects of high-intensity exercise on blood pressure, cholesterol, and oxygen utilization.

#exercise

#supplement

Avoid calcium supplements to reduce heart attack risk

Taking calcium supplements is linked to a 30-90% increased risk of heart attacks because they spike blood calcium levels, unlike dietary calcium.

#calcium

#heart

Reevaluate resveratrol's role in activating SIRT1 for longevity

Recent research using CRISPR technology found that resveratrol does not directly activate the longevity enzyme SIRT1, but instead stresses cells by interfering with DNA copying.