Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder

Andrew Huberman

Sep 8, 2025

Episode description

My guest is Dr. Michael Snyder, PhD, professor of genetics at Stanford and an expert in understanding why people respond differently to various foods, supplements, behavioral and prescription interventions. We discuss how to optimize your health and lifespan according to what type of glucose responder you are, which genes you express, your lifestyle and other factors. Dr. Snyder also explains the key ages when you need to be particularly mindful about following certain health practices. We also discuss how people respond in opposite ways to different fiber types. This episode ought to be of interest and use to anyone seeking to understand their unique biological needs and how to go about meeting those needs.

Episode show notes: https://go.hubermanlab.com/yQHG6sg

*Thank you to our sponsors*
AGZ by AG1: https://drinkag1.com/huberman
Wealthfront*: https://wealthfront.com/huberman
David: https://davidprotein.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Function: https://functionhealth.com/huberman

_*This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer._

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*Dr. Michael Snyder*
Stanford academic profile: https://med.stanford.edu/snyderlab/about.html
Lab website: https://med.stanford.edu/snyderlab.html
AI Longevity Lab: https://www.eventbrite.com/e/stanford-genetics-department-ai-longevity-lab-certificate-tickets-1641608327699
Book: https://amzn.to/4m3ILuM
X: https://x.com/snydershot
LinkedIn: https://www.linkedin.com/in/mpsnyder1
Facebook: https://www.facebook.com/snyder.labs
YouTube: https://www.youtube.com/playlist?list=PLNId-2r6JNxEHXqJXqsbe_h3RnZuBlfe5

*Timestamps*
00:00:00 Michael Snyder
00:03:33 Healthy Glucose Range, Continuous Glucose Monitors (CGM), Hemoglobin A1c
00:09:02 Individual Variability & Food Choice, Glucose Spikes & Sleepiness
00:12:18 Sponsors: AGZ by AG1 & Wealthfront
00:15:16 Glucose Spikes, Tools: Post-Meal Brisk Walk; Soleus “Push-Ups”; Exercise Snacks
00:21:06 Glucose Dysregulation, Diabetes & Sub-Phenotypes, Tool: Larger Morning Meal
00:28:34 Exercise Timing, Muscle Insulin Resistance
00:30:49 Diabetes Subtyping, Weight, Glucose Control; Incretins
00:35:41 GLP-1 Agonists, Diabetes, Tool: Muscle Maintenance & Resistance Training
00:38:40 Metformin, Berberine, Headaches
00:41:01 GLP-1 Agonists, Cognition, Longevity, Tool: Habits Support Medication; Cycling
00:47:41 Subcutaneous vs Visceral Fat, Organ Stress
00:49:10 Sponsors: David & Eight Sleep
00:51:58 Meal Timing & Sleep, Tools: Post-Dinner Walk, Routines, Bedtime Consistency
00:57:16 Microbiome, Immune System & Gut; Diet & Individual Variability
01:02:52 Fiber Types, Cholesterol & Glucose, Polyphenols
01:09:50 Food As Medicine; Fiber, Microbiome & Individual Variability; Probiotics
01:18:48 Sponsor: Function
01:20:35 Profiling Healthy Individuals, Genomes, Wearables
01:26:31 Whole-Body MRIs, Nodules, Healthy Baseline, Early Diagnosis
01:34:07 Sensors, CGM, Sleep, Heart Rate Variability (HRV), Tools: Mindset Effects, Increase REM
01:39:30 HRV, Sleep, Exercise, Tool: Long Exhales; Next-Day Excitement & Sleep
01:42:48 Organ Aging, “Ageotypes”; Biological Age vs Chronological Age
01:49:41 Longevity, Health Span, Genetics, Blue Zones
01:52:19 Epigenetics, Viral Infection & Disease
01:58:54 ALS, Heritability; Neuroprotection, Nicotine
02:03:47 Air Quality, Allergies, DEET & Pesticides, Inflammation, Mold; Microplastics
02:15:02 Single-Drop Blood Test & Biomarkers, Wearables, Observational Trials
02:20:33 Acupuncture, Blood Pressure
02:26:40 Immersive Events & Mental Health Benefits
02:34:59 Data, Nutrition & Lifestyle; Siloed Health Care vs Personalized Medicine
02:43:06 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Episode description

My guest is Dr. Michael Snyder, PhD, professor of genetics at Stanford and an expert in understanding why people respond differently to various foods, supplements, behavioral and prescription interventions. We discuss how to optimize your health and lifespan according to what type of glucose responder you are, which genes you express, your lifestyle and other factors. Dr. Snyder also explains the key ages when you need to be particularly mindful about following certain health practices. We also discuss how people respond in opposite ways to different fiber types. This episode ought to be of interest and use to anyone seeking to understand their unique biological needs and how to go about meeting those needs.

Episode show notes: https://go.hubermanlab.com/yQHG6sg

*Thank you to our sponsors*
AGZ by AG1: https://drinkag1.com/huberman
Wealthfront*: https://wealthfront.com/huberman
David: https://davidprotein.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Function: https://functionhealth.com/huberman

_*This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer._

*Follow Huberman Lab*
Instagram: https://www.instagram.com/hubermanlab
Threads: https://www.threads.net/@hubermanlab
X: https://twitter.com/hubermanlab
Facebook: https://www.facebook.com/hubermanlab
TikTok: https://www.tiktok.com/@hubermanlab
LinkedIn: https://www.linkedin.com/in/andrew-huberman
Website: https://www.hubermanlab.com
Newsletter: https://www.hubermanlab.com/newsletter

*Dr. Michael Snyder*
Stanford academic profile: https://med.stanford.edu/snyderlab/about.html
Lab website: https://med.stanford.edu/snyderlab.html
AI Longevity Lab: https://www.eventbrite.com/e/stanford-genetics-department-ai-longevity-lab-certificate-tickets-1641608327699
Book: https://amzn.to/4m3ILuM
X: https://x.com/snydershot
LinkedIn: https://www.linkedin.com/in/mpsnyder1
Facebook: https://www.facebook.com/snyder.labs
YouTube: https://www.youtube.com/playlist?list=PLNId-2r6JNxEHXqJXqsbe_h3RnZuBlfe5

*Timestamps*
00:00:00 Michael Snyder
00:03:33 Healthy Glucose Range, Continuous Glucose Monitors (CGM), Hemoglobin A1c
00:09:02 Individual Variability & Food Choice, Glucose Spikes & Sleepiness
00:12:18 Sponsors: AGZ by AG1 & Wealthfront
00:15:16 Glucose Spikes, Tools: Post-Meal Brisk Walk; Soleus “Push-Ups”; Exercise Snacks
00:21:06 Glucose Dysregulation, Diabetes & Sub-Phenotypes, Tool: Larger Morning Meal
00:28:34 Exercise Timing, Muscle Insulin Resistance
00:30:49 Diabetes Subtyping, Weight, Glucose Control; Incretins
00:35:41 GLP-1 Agonists, Diabetes, Tool: Muscle Maintenance & Resistance Training
00:38:40 Metformin, Berberine, Headaches
00:41:01 GLP-1 Agonists, Cognition, Longevity, Tool: Habits Support Medication; Cycling
00:47:41 Subcutaneous vs Visceral Fat, Organ Stress
00:49:10 Sponsors: David & Eight Sleep
00:51:58 Meal Timing & Sleep, Tools: Post-Dinner Walk, Routines, Bedtime Consistency
00:57:16 Microbiome, Immune System & Gut; Diet & Individual Variability
01:02:52 Fiber Types, Cholesterol & Glucose, Polyphenols
01:09:50 Food As Medicine; Fiber, Microbiome & Individual Variability; Probiotics
01:18:48 Sponsor: Function
01:20:35 Profiling Healthy Individuals, Genomes, Wearables
01:26:31 Whole-Body MRIs, Nodules, Healthy Baseline, Early Diagnosis
01:34:07 Sensors, CGM, Sleep, Heart Rate Variability (HRV), Tools: Mindset Effects, Increase REM
01:39:30 HRV, Sleep, Exercise, Tool: Long Exhales; Next-Day Excitement & Sleep
01:42:48 Organ Aging, “Ageotypes”; Biological Age vs Chronological Age
01:49:41 Longevity, Health Span, Genetics, Blue Zones
01:52:19 Epigenetics, Viral Infection & Disease
01:58:54 ALS, Heritability; Neuroprotection, Nicotine
02:03:47 Air Quality, Allergies, DEET & Pesticides, Inflammation, Mold; Microplastics
02:15:02 Single-Drop Blood Test & Biomarkers, Wearables, Observational Trials
02:20:33 Acupuncture, Blood Pressure
02:26:40 Immersive Events & Mental Health Benefits
02:34:59 Data, Nutrition & Lifestyle; Siloed Health Care vs Personalized Medicine
02:43:06 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Mindsip insights from this episode:

Explore GLP-1 agonists for cognitive enhancement and longevity

GLP-1 agonists like Ozempic are being explored as potential longevity drugs, partly due to evidence they may improve cognition.

Personalize fiber intake to optimize cholesterol reduction

In a study, Arabinoxylan fiber (in Metamucil) lowered cholesterol for most, but for some individuals, Inulin was more effective.

Recognize type 2 diabetes sub-phenotypes for tailored treatments

Type 2 diabetes is not a single disease but can be subdivided into different forms like muscle resistance or beta-cell defects, which require different treatments.

Exercise in the morning to improve glucose control for insulin resistance

People with muscle insulin resistance get better glucose control benefits by exercising in the morning, which is contrary to general advice.

Identify fibers that may trigger inflammation in your body

Contrary to popular belief, certain types of fiber can cause systemic inflammation in some individuals while reducing it in others.

Understand personal glycemic responses to optimize diet

The glycemic index is highly personal, with some people spiking glucose to potatoes but not grapes, and vice versa.

Recognize viral infections as triggers for diabetes risk

A viral infection can trigger latent, genetically-predisposed diabetes by causing long-term epigenetic changes to metabolic genes.

Engage in immersive events to enhance mental health and reduce inflammation

Immersive psychological events, like those from Tony Robbins, have been shown in studies to improve not just mental health surveys but also physical inflammatory markers.

Prioritize ageotypes over biological age for actionable health interventions

Instead of a single biological age, we have personal aging pathways called 'ageotypes' (e.g., metabolic, immune) which are more actionable for health interventions.

Utilize Iollo home test to discover your personal ageotype

A commercially available home test from a company called Iollo uses a few drops of blood to profile 650 metabolites and determine your personal ageotype.

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© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius