Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days
Mark Hyman
Jun 8, 2026
Episode description
High cholesterol is one of the most common reasons people are told they’re at risk for heart disease. But what if cholesterol isn’t the root problem? What if it’s actually a signal of deeper metabolic dysfunction—and focusing on the number alone causes us to miss what’s really driving cardiovascular risk?
In today’s episode, we explore a functional medicine approach to cholesterol and heart health, including:
Why high cholesterol is often a downstream effect of insulin resistance, inflammation, and metabolic dysfunction
The surprising role sugar, refined carbohydrates, and ultra-processed foods play in driving unhealthy cholesterol patterns
How healthy fats, protein, fiber, and gut health influence cholesterol regulation and cardiovascular risk
The nutrition and lifestyle changes that can improve metabolic health—and begin shifting key biomarkers in as little as 10 days
When it comes to cholesterol, the better question isn’t always, "How do I lower this number?" It’s, "Why is it elevated in the first place?" By addressing the root causes—from blood sugar imbalance and inflammation to diet, movement, sleep, and stress—you can improve not just your cholesterol, but the underlying metabolic health that drives long-term cardiovascular risk.
Resources Mentioned:
Learn more about the 10-Day Detox: https://bit.ly/3PIUoxf
Listen to my full conversation with Dr. Aseem Malhotra: https://bit.ly/4x5wEUR
Track your metabolic and cardiovascular health biomarkers: functionhealth.com/mark for 160+ lab tests at just $365/year. Use code MARK2026 for $50 off.
Have a question you'd love answered on Office Hours? Submit it here
(0:25) Introduction
(1:11) Understanding and Addressing Cholesterol with Functional Medicine
(2:20) Metabolic Dysfunction, Health Reset, and Dietary Recommendations
(8:07) Example Daily Meal Plan and Importance of Movement
(12:46) Sleep, Stress, and Supplements for Cholesterol
(14:27) Cardiovascular Risk Insights and Dr. Asim Malhotra Clip
(20:30) Closing Remarks, Listener Engagement, and Social Media
(21:57) Disclaimer, Medical Guidance, and Gratitude to Sponsors
Mindsip insights from this episode:
More from
Mark Hyman

Too Much Histamine Is Wrecking Your Body — And Most Doctors Don't Know It

How Brain Inflammation Drives Depression, Alzheimer's, and Parkinson's

Your Nervous System Controls Your Gut, Hormones, and Weight — Here's How to Fix It

3 Heart Experts Reveal What Really Prevents Heart Disease

Encore: Why Normal Cholesterol Doesn't Always Mean Low Heart Disease Risk
You also might be interested in

This Ancient Hack Reverses Aging In 72 Hours

The Potent Brain & Body Ketone Fuel You’ve Probably Never Heard Of: The Science Of R3HBG With Tecton’s Dr. Mike Chesne

1 Year of Lutein: Reversing Arterial Plaque

How To Maintain Muscle On A GLP-1, Why Protein Stops Working As You Get Older, The Truth About Eating “Before Bedtime” & More! Solosode #502

Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett






