Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days

Mark Hyman

Jun 8, 2026

Episode description

High cholesterol is one of the most common reasons people are told they’re at risk for heart disease. But what if cholesterol isn’t the root problem? What if it’s actually a signal of deeper metabolic dysfunction—and focusing on the number alone causes us to miss what’s really driving cardiovascular risk?

In today’s episode, we explore a functional medicine approach to cholesterol and heart health, including:

  • Why high cholesterol is often a downstream effect of insulin resistance, inflammation, and metabolic dysfunction

  • The surprising role sugar, refined carbohydrates, and ultra-processed foods play in driving unhealthy cholesterol patterns

  • How healthy fats, protein, fiber, and gut health influence cholesterol regulation and cardiovascular risk

  • The nutrition and lifestyle changes that can improve metabolic health—and begin shifting key biomarkers in as little as 10 days

When it comes to cholesterol, the better question isn’t always, "How do I lower this number?" It’s, "Why is it elevated in the first place?" By addressing the root causes—from blood sugar imbalance and inflammation to diet, movement, sleep, and stress—you can improve not just your cholesterol, but the underlying metabolic health that drives long-term cardiovascular risk.

Resources Mentioned:

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(0:25) Introduction

(1:11) Understanding and Addressing Cholesterol with Functional Medicine

(2:20) Metabolic Dysfunction, Health Reset, and Dietary Recommendations

(8:07) Example Daily Meal Plan and Importance of Movement

(12:46) Sleep, Stress, and Supplements for Cholesterol

(14:27) Cardiovascular Risk Insights and Dr. Asim Malhotra Clip

(20:30) Closing Remarks, Listener Engagement, and Social Media

(21:57) Disclaimer, Medical Guidance, and Gratitude to Sponsors



Mindsip insights from this episode:

Lab test your health annually with Function Health's comprehensive service

The service Function Health provides access to over 160 lab tests for an annual fee to help you stop guessing and check what's happening inside your body.

Prioritize reducing sugar intake to manage cholesterol levels

For many people, a diet high in sugar and processed carbs is a bigger driver of high cholesterol than dietary fat due to its effect on insulin resistance.

Practice Raj Yoga meditation to reverse heart disease

A study in India found that 40 minutes of Raj Yoga meditation per day was the only independent factor linked to the reversal of coronary artery blockages.

Utilize soluble fibers to eliminate excess cholesterol

Soluble fibers like psyllium husk or glucomannan can help bind excess cholesterol in the gut and support its removal from the body.

Maintain healthy muscle mass to enhance metabolic function

Muscle acts as a metabolic organ, and maintaining more healthy muscle mass improves your body's ability to manage blood sugar and cholesterol.

Walk ten minutes after meals to enhance blood sugar regulation

Even a 10-minute walk after meals can help improve blood sugar regulation and support your metabolic health.

Correct insulin to normalize heart disease risk in genetic high cholesterol

For patients with genetic high cholesterol (FH), correcting insulin resistance can almost completely normalize their risk of heart disease.

Address metabolic dysfunction to resolve high cholesterol issues

High cholesterol is often not the root problem but a downstream effect of metabolic dysfunction, inflammation, and high blood sugar.

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