Your Arteries are Diseased - THIS is how you Restore them!

Physionic

Jul 21, 2025

Episode description

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0:00 - Introduction
1:33 - A Shift in Metabolism...
4:15 - Why do our arteries prefer this metabolic state?
9:54 - What can we do to fix these arterial problems?
13:51 - Main Points

Reference
[Study 490] Kalucka J, Bierhansl L, Vasconcelos Conchinha N, et al. Quiescent endothelial cells upregulate fatty acid β‑oxidation for vasculoprotection via redox homeostasis. Cell Metab. 2018;28(6):881‑894. doi:10.1016/j.cmet.2018.07.016

Funding/Conflicts: Mixed Funding [Public: Research Foundation Flanders (FWO), the Federal Government of Belgium (IUAP7/03), the Flemish Government through Methusalem structural funding, the Swiss National Science Foundation, the British Heart Foundation, the National Natural Science Foundation of China, and several European Union programs including the Marie Curie CIG and ERC Advanced Research Grant (EU-ERC743074). Additional public support came from institutions such as the State Key Laboratory of Ophthalmology (China) and the VIB Tech-Watch Program in Belgium.; Non-Profit: Leopoldina Postdoctoral Scholarship (Germany), the Fritz Thyssen Stiftung, and the Foundation Against Cancer (Belgium). // Potential direct Conflicts of Interest [Peter Carmeliet (P.C.) is named as an inventor on patent applications related to the findings in this paper; All other authors declare no competing interests.]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#hearthealth #heartdisease

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:33 - A Shift in Metabolism...
4:15 - Why do our arteries prefer this metabolic state?
9:54 - What can we do to fix these arterial problems?
13:51 - Main Points

Reference
[Study 490] Kalucka J, Bierhansl L, Vasconcelos Conchinha N, et al. Quiescent endothelial cells upregulate fatty acid β‑oxidation for vasculoprotection via redox homeostasis. Cell Metab. 2018;28(6):881‑894. doi:10.1016/j.cmet.2018.07.016

Funding/Conflicts: Mixed Funding [Public: Research Foundation Flanders (FWO), the Federal Government of Belgium (IUAP7/03), the Flemish Government through Methusalem structural funding, the Swiss National Science Foundation, the British Heart Foundation, the National Natural Science Foundation of China, and several European Union programs including the Marie Curie CIG and ERC Advanced Research Grant (EU-ERC743074). Additional public support came from institutions such as the State Key Laboratory of Ophthalmology (China) and the VIB Tech-Watch Program in Belgium.; Non-Profit: Leopoldina Postdoctoral Scholarship (Germany), the Fritz Thyssen Stiftung, and the Foundation Against Cancer (Belgium). // Potential direct Conflicts of Interest [Peter Carmeliet (P.C.) is named as an inventor on patent applications related to the findings in this paper; All other authors declare no competing interests.]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#hearthealth #heartdisease

Mindsip insights from this episode:

Boost cell antioxidants through fat metabolism

Fat metabolism is protective for artery-lining cells because it produces citrate, which ultimately helps recharge the potent cellular antioxidant glutathione to fight damaging reactive oxygen species.

Utilize acetate to fuel protective fat metabolism despite impairments

The short-chain fat acetate can diffuse across the mitochondrial membrane without needing the CPT1 protein, providing a way to fuel protective fat metabolism even when it's impaired.

Prioritize fat for energy to support healthy artery cells

Healthy, quiescent endothelial cells that line your arteries prefer to use fat for energy, whereas stressed, proliferating cells switch to using sugar.

Improve fat metabolism to reduce cardiovascular risk

When fat metabolism is blocked in endothelial cells, they produce more of a protein called PAI-1, which inhibits the breakdown of blood clots and increases cardiovascular risk.

Boost acetate levels with fiber and vinegar-rich foods

You can increase your body's levels of the beneficial short-chain fat acetate by consuming dietary fiber from sources like legumes and whole grains, as well as vinegar-based foods and fermented tea.

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