Your Skin Loses 75% of This by Age 75 (New Fix)

Brad Stanfield

Mar 18, 2026

Episode description

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Timestamps:
00:00 Hyaluronic Acid Problems
00:52 Studies on Hyaluronic Acid and Skin Health
02:46 Understanding Absorption of Hyaluronic Acid
05:14 New Findings on Absorption
07:00 New Clinical Trial on Hyaluronic Acid
08:44 Possible Mechanisms of Action
00:09:46 Key Takeaways

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Here are the links to the research papers referenced in the video:
https://www.sciencedirect.com/science/article/abs/pii/S0144861723003454?via%3Dihub
Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid

https://www.nature.com/articles/s41598-025-32758-5
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522662/
Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period

https://pmc.ncbi.nlm.nih.gov/articles/PMC4110621/
Ingested hyaluronan moisturizes dry skin

https://pubmed.ncbi.nlm.nih.gov/34933842/
Oral intake of a new full-spectrum hyaluronan improves skin profilometry and ageing: a randomized, double-blind, placebo-controlled clinical trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661223/
Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test, 2023

https://pmc.ncbi.nlm.nih.gov/articles/PMC10082573/
The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review

https://pubs.acs.org/doi/10.1021/jf8017029
Absorption, Uptake and Tissue Affinity of High-Molecular-Weight Hyaluronan after Oral Administration in Rats and Dogs

https://pmc.ncbi.nlm.nih.gov/articles/PMC3512263/
Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Mindsip insights from this episode:

Leverage gut bacteria to absorb hyaluronic acid

Gut bacteria are required to break down hyaluronic acid into a form that can actually be absorbed by the body.

#bacteria

#digestion

Maximize hyaluronic acid absorption for better results

Even with the help of gut bacteria, the bioavailability of hyaluronic acid is very low, with just 0.2% of the supplement being absorbed.

#bioavailability

#hyaluronic-acid

Avoid expensive high molecular weight hyaluronic acid for no added benefit

There is no additional benefit to taking expensive high molecular weight hyaluronic acid, as it just gets broken down anyway.

#hyaluronic-acid

#supplement

Leverage hyaluronic acid to enhance gut microbiome and collagen production

The benefits of hyaluronic acid supplements appear to be indirect, possibly by improving the gut microbiome or stimulating the body's own production of collagen and HA.