#1 Longevity Expert: Fastest Way To Get Alzheimer's & A Decreased Lifespan (You're Probably Doing!)
Rangan Chatterjee
Jul 16, 2025
Episode description
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Did you know that your daily habits directly affect the speed at which your brain is ageing and your risk of getting Alzheimer’s disease in the future?
This week, I'm delighted to welcome Dr Darshan Shah to the podcast. Darshan is a medical doctor, a board-certified surgeon, an expert in preventive health and the founder of Next Health, the first health optimisation and longevity centre to offer life-extending and enhancing technology and treatments.
Whilst working as a surgeon, Darshan became seriously ill with type diabetes, hypertension, an autoimmune condition, and he was told he had a 50% chance of dying in the next 25 years. This wake-up call came just as his first son was born. Rather than accepting a life dependent on medications, he immersed himself in functional medicine and completely reversed his conditions in just eight months.
During our conversation, you'll discover:
• The 5 things you could start doing today that would actually increase your chances of getting Alzheimer’s
• The 80/20 principle for health and how focusing on just 20% of interventions can deliver 80% of the results
• Why sitting for more than four hours increases your risk of death by 15%
• Why becoming the "boss of your own biology" through tracking key biomarkers could be life-saving
• How inflammation from your gut and mouth can directly impact your brain health decades later
• Darshan’s top supplement recommendations for longevity
This conversation challenges the notion that we can simply live intuitively in today's environment and expect to stay healthy. Darshan argues that in our current toxic world, taking an active role in monitoring and optimising our health isn't just beneficial, it's essential.
Whether you're interested in detailed health tracking or just want to learn the basics of staying well, this conversation is packed with practical advice that could transform how you think about your health. I hope you enjoy listening.
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Connect with Darshan:
Instagram https://www.instagram.com/darshanshahmd/
YouTube https://www.youtube.com/darshanshahmd
Extend Podcast https://podcasts.apple.com/us/podcast/extend-podcast-with-darshan-shah-md/id1773578243
Dr Shah's Biomarkers Guide: https://www.drshah.com/biomarkers
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DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.
Mindsip insights from this episode:
Eliminate ultra-processed foods for better health
Focusing on eliminating ultra-processed foods from your diet is far more impactful for your health than adding in small amounts of healthy foods.
Recognize testosterone's role in brain health to reduce Alzheimer's risk
Testosterone is not just for libido; it's a critical trophic factor that signals growth and health to the brain, and low levels are a risk factor for Alzheimer's.
Consider Urolithin A and Nicotinamide Riboside for mitochondrial health
For advanced supplementation, consider Urolithin A from Timeline Nutrition and Nicotinamide Riboside from True Niagen to improve mitochondrial health.
Ruck with weight to enhance balance and strength
Walking or hiking with a weighted backpack, or 'rucking,' helps preserve balance and lower body strength, which is crucial for preventing falls in old age.
Reevaluate normal lab results for optimal health
Standard laboratory reference ranges for markers like testosterone and liver enzymes have shifted over time to reflect a sicker population, so a 'normal' result may not be optimal for health.
Reduce Alzheimer's risk by addressing head trauma, metabolic health, inflammation, toxins, and stress
You can increase your risk of Alzheimer's through head trauma, poor metabolic health, inflammation, toxin exposure, and chronic stress.
Prioritize movement throughout the day to counteract sedentary effects
Exercising for an hour at the gym does not negate the negative health effects of being sedentary for the rest of the day.
Avoid paper coffee cups to reduce microplastic exposure
Paper coffee cups are lined with plastic, and drinking hot beverages from them is a major source of microplastic exposure linked to vascular and brain disease.
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