2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann

Dave Asprey

Jan 21, 2025

Episode description

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?

Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.

From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.

What You’ll Learn:

• The Seven Tenets of Aging and how they’ll change your approach to health

• Why indulging in “bad” habits doesn’t have to sabotage your longevity

• Biochemical secrets to combat oxidative stress, glycation, and cellular junk

• The real story behind NAD, circadian rhythms, and the tools for better sleep

• How to create a personalized health plan that’s sustainable, effective—and fun

Resources:

• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Kaufmann Protocol Website: https://kaufmannprotocol.com

• Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047

• Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Book – Smarter Not Harder:

Mindsip insights from this episode:

Utilize birth control pills to preserve youthful hormonal balance for longevity

Taking birth control pills can be a longevity strategy for women by preserving the homeostatic, cyclical hormonal patterns of a 30-year-old, provided you block the potential negative side effects.

#birth-control

#longevity

Block negative aging pathways to enjoy life's pleasures

A core longevity philosophy is to use pharmaceuticals to block negative aging pathways, allowing you to enjoy things like Diet Coke and cupcakes without paying the full biological price.

#longevity

Activate ROR alpha pathway with nobilitin for deeper sleep

The orange peel extract nobilitin can increase the depth and amplitude of sleep by activating the ROR alpha circadian pathway.

#sleep

#supplement

Avoid high-dose IV NAD therapy to protect metabolic health

High-dose IV NAD therapy can be metabolically toxic because it breaks down into NAM, which negatively impacts crucial enzymes like sirtuins.

#NAD

#supplement

Take diverse NAD precursors for optimal tissue support

You should take a small dose of all NAD precursors—tryptophan, NR, NMN, and direct NAD—because different tissues in the body, like the brain and muscles, prefer different forms.

#NAD

#supplement

Utilize hydralazine to prevent harmful glycation in proteins

The blood pressure medication hydralazine can act as a decoy for excess glucose, preventing it from sticking to proteins and forming damaging advanced glycation end-products (AGEs).

#blood-pressure

Utilize Selbeks to mimic sauna benefits for neurologic health

The drug Selbeks is a heat shock protein activator that functions like a 'sauna in a pill' and may reduce the risk of neurologic diseases by improving protein refolding.

#neurology

Consider higher lithium doses for enhanced longevity and mood benefits

Taking a pharmaceutical dose of lithium, such as 75mg, may offer more significant longevity benefits for telomeres and mood than the common practice of microdosing lithium orotate.