
Collagen for Skin 'Debunked', Non-Nutritive Sweeteners on Cognitive Decline, Seed Oils, and More
Physionic
Oct 25, 2025
Mindsip insights from this episode:
Understand ketones as liver protection mechanism
The liver produces ketones as a protective 'release valve' to manage fat accumulation, meaning high ketones can be a response to, not a cause of, poor liver health.
Question non-nutritive sweeteners' long-term safety for cognitive health
The concern about non-nutritive sweeteners and cognitive health stems not just from one negative study, but from a surprising lack of randomized trials proving their long-term safety for the brain.
Clarify collagen study findings to reveal benefits
A meta-analysis concluded non-industry-funded collagen studies showed no effect, but this was due to a lack of statistical power, as 6 out of the 7 individual studies actually showed a benefit.
Utilize collagen peptides to enhance collagen production
The argument for collagen peptides is that they act as signaling molecules that bind to cell surface receptors, convincing the cell to produce more mature collagen fibers.
Reassess seed oil risk based on omega-6 to omega-3 ratio
Large-scale data shows the typical population's omega-6 to omega-3 consumption ratio, while not ideal, is still within a range not associated with increased cardiovascular risk.
Critique flawed creatine study on muscle growth effectiveness
A study claiming creatine is ineffective for muscle growth was flawed because it equalized workout volume, removing the main mechanism by which creatine enhances performance and subsequent growth.
Utilize butyrate to eliminate colon cancer cells
The short-chain fat butyrate can kill colon cancer cells by accumulating inside them and altering their gene expression to shut down growth and promote cell death.
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