Does Nattokinase improve Heart Disease? [Study 269-276 Analysis]

Physionic

Apr 10, 2024

Episode description

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Created with Biorender

Created with Biorender

Studies, Notes, & Amendments: https://bit.ly/PhysionicNattokinaseforHeartDisease

0:00 - Introduction
1:35 - Covered Topics
2:44 - Mechanisms of Action
18:10 - Nattokinase on Blood Sugar and Lipids
18:29 - Study 269: The Meta-Analysis
22:57 - Total Cholesterol / How to Read the Analysis
31:21 - Critique of the Analysis
36:05 - High Density Lipoprotein (HDL)
37:32 - Low Density Lipoproteins (LDL)
38:18 - Triglycerides
38:48 - Blood Glucose
39:13 - Study 274: Nattokinase for High Cholesterol Individuals
46:04 - Study 276: Nattokinase for High Cholesterol Women
50:49 - Study 275: Nattokinase Long-Term Exposure
54:14 - Study 272: Nattokinase for People with Known Arterial Plaque
1:00:24 - Nattokinase on Blood Pressure
1:00:32 - Study 269: The Meta-Analysis
1:02:11 - Study 270: Nattokinase for Elderly with High Blood Pressure
1:07:09 - Study 271: Nattokinase for People with High Blood Pressure
1:11:19 - Study 275: Nattokinase for People with Normal Blood Pressure
1:12:42 - Mid-Point Conclusions

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#nattokinase #heartdiseaseprevention

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H


Created with Biorender

Created with Biorender

Studies, Notes, & Amendments: https://bit.ly/PhysionicNattokinaseforHeartDisease

0:00 - Introduction
1:35 - Covered Topics
2:44 - Mechanisms of Action
18:10 - Nattokinase on Blood Sugar and Lipids
18:29 - Study 269: The Meta-Analysis
22:57 - Total Cholesterol / How to Read the Analysis
31:21 - Critique of the Analysis
36:05 - High Density Lipoprotein (HDL)
37:32 - Low Density Lipoproteins (LDL)
38:18 - Triglycerides
38:48 - Blood Glucose
39:13 - Study 274: Nattokinase for High Cholesterol Individuals
46:04 - Study 276: Nattokinase for High Cholesterol Women
50:49 - Study 275: Nattokinase Long-Term Exposure
54:14 - Study 272: Nattokinase for People with Known Arterial Plaque
1:00:24 - Nattokinase on Blood Pressure
1:00:32 - Study 269: The Meta-Analysis
1:02:11 - Study 270: Nattokinase for Elderly with High Blood Pressure
1:07:09 - Study 271: Nattokinase for People with High Blood Pressure
1:11:19 - Study 275: Nattokinase for People with Normal Blood Pressure
1:12:42 - Mid-Point Conclusions

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#nattokinase #heartdiseaseprevention

Mindsip insights from this episode:

Debunk myths: Nattokinase does not affect cholesterol levels

Despite a flawed meta-analysis suggesting otherwise, a deeper look at the individual studies shows nattokinase supplementation does not negatively impact cholesterol-containing lipoproteins or blood glucose levels.

Clarify nattokinase as a cleavage enzyme, not a kinase

The supplement is incorrectly named, as it is not a 'kinase' but rather a protein that functions as a cleavage enzyme.

Utilize nattokinase to dissolve blood clots

Nattokinase can act as a cleavage enzyme, directly binding to and breaking up fibrin, the stringy protein that holds blood clots together.

Reevaluate nattokinase study to correct cholesterol conclusions

A key meta-analysis on nattokinase is likely wrong because it compared end-of-study results instead of the change from baseline, incorrectly concluding that the supplement raises cholesterol.

Recognize male-specific blood pressure benefits of nattokinase

In one study, the diastolic blood pressure-lowering effect of nattokinase was solely driven by men, implying women may not receive the same benefit.

Recognize nattokinase's lack of impact on metabolism

One study that measured total energy expenditure found that nattokinase had absolutely zero effect on metabolism.

Utilize nattokinase to lower blood pressure in hypertensive individuals

Nattokinase appears to lower blood pressure only in hypertensive individuals, as a three-year study on people with normal blood pressure showed no effect.

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