
Does Nattokinase improve Heart Disease? [Study 269-276 Analysis]
Physionic
Apr 10, 2024
Mindsip insights from this episode:
Debunk myths: Nattokinase does not affect cholesterol levels
Despite a flawed meta-analysis suggesting otherwise, a deeper look at the individual studies shows nattokinase supplementation does not negatively impact cholesterol-containing lipoproteins or blood glucose levels.
Clarify nattokinase as a cleavage enzyme, not a kinase
The supplement is incorrectly named, as it is not a 'kinase' but rather a protein that functions as a cleavage enzyme.
Utilize nattokinase to dissolve blood clots
Nattokinase can act as a cleavage enzyme, directly binding to and breaking up fibrin, the stringy protein that holds blood clots together.
Reevaluate nattokinase study to correct cholesterol conclusions
A key meta-analysis on nattokinase is likely wrong because it compared end-of-study results instead of the change from baseline, incorrectly concluding that the supplement raises cholesterol.
Recognize male-specific blood pressure benefits of nattokinase
In one study, the diastolic blood pressure-lowering effect of nattokinase was solely driven by men, implying women may not receive the same benefit.
Recognize nattokinase's lack of impact on metabolism
One study that measured total energy expenditure found that nattokinase had absolutely zero effect on metabolism.
Utilize nattokinase to lower blood pressure in hypertensive individuals
Nattokinase appears to lower blood pressure only in hypertensive individuals, as a three-year study on people with normal blood pressure showed no effect.
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