HMB: Protecting against Age-related Muscle Loss

Episode description

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Created with Biorender

Creatine for Sarcopenia: https://youtu.be/EF96KabVAXM

0:00 - Introduction
0:31 - HMB
2:21 - Is it Worthwhile to Supplement?
4:20 - Context Matters
5:05 - Better than other Supplements? Leucine, Protein?
5:59 - Type of HMB Matters..
6:18 - Main Points

References
[Study 520] Li N, Chen S, He Y, Chen Y, Duan X, He W, Wang Q, Liu S, Liu T, Fang H. Effects of oral supplementation of β-hydroxy-β-methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis. Front Nutr. 2025;12:1522287. doi:10.3389/fnut.2025.1522287.
Funding/Conflicts: Public Funding: Ministry of Science and Technology of the People’s Republic of China (grant 2022YFF1100605); Non-Profit Funding: Chinese Institute of Food Science and Technology (grant 2022-F01); Industry Funding: none reported// Conflicts of Interest: authors state no commercial or financial relationships that could be construed as a potential conflict of interest.

[Study 521] Feng Y, Chen P, Li T, Wan P, Shi R. Effects of exercise with or without β-hydroxy-β-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in patients with sarcopenia: a systematic review and meta-analysis. Front Nutr. 2024;11:1460133. doi:10.3389/fnut.2024.1460133.

Funding/Conflicts: Public Funding: National Natural Science Foundation of China (32171136); Natural Science Foundation of Shanghai (19ZR1452900); Key R&D Project of the Ministry of Science and Technology (2020YFC2005604); Shanghai Frontiers Science Research Base of Exercise and Metabolic Health; Research and Innovation Grant for Graduate Students, Shanghai University of Sport (YJSCX-2024-021); Non-Profit Funding: none reported; Industry Funding: none reported // Conflicts of Interest: authors declare the research was conducted in the absence of commercial or financial relationships that could be construed as a potential conflict of interest.

[A] Rathmacher JA, Pitchford LM, Stout JR, et al. International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB). J Int Soc Sports Nutr. 2025;22(1):2434734. doi:10.1080/15502783.2024.2434734

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#HMB #sarcopenia #sarcopeniaprevention

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

Creatine for Sarcopenia: https://youtu.be/EF96KabVAXM

0:00 - Introduction
0:31 - HMB
2:21 - Is it Worthwhile to Supplement?
4:20 - Context Matters
5:05 - Better than other Supplements? Leucine, Protein?
5:59 - Type of HMB Matters..
6:18 - Main Points

References
[Study 520] Li N, Chen S, He Y, Chen Y, Duan X, He W, Wang Q, Liu S, Liu T, Fang H. Effects of oral supplementation of β-hydroxy-β-methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis. Front Nutr. 2025;12:1522287. doi:10.3389/fnut.2025.1522287.
Funding/Conflicts: Public Funding: Ministry of Science and Technology of the People’s Republic of China (grant 2022YFF1100605); Non-Profit Funding: Chinese Institute of Food Science and Technology (grant 2022-F01); Industry Funding: none reported// Conflicts of Interest: authors state no commercial or financial relationships that could be construed as a potential conflict of interest.

[Study 521] Feng Y, Chen P, Li T, Wan P, Shi R. Effects of exercise with or without β-hydroxy-β-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in patients with sarcopenia: a systematic review and meta-analysis. Front Nutr. 2024;11:1460133. doi:10.3389/fnut.2024.1460133.

Funding/Conflicts: Public Funding: National Natural Science Foundation of China (32171136); Natural Science Foundation of Shanghai (19ZR1452900); Key R&D Project of the Ministry of Science and Technology (2020YFC2005604); Shanghai Frontiers Science Research Base of Exercise and Metabolic Health; Research and Innovation Grant for Graduate Students, Shanghai University of Sport (YJSCX-2024-021); Non-Profit Funding: none reported; Industry Funding: none reported // Conflicts of Interest: authors declare the research was conducted in the absence of commercial or financial relationships that could be construed as a potential conflict of interest.

[A] Rathmacher JA, Pitchford LM, Stout JR, et al. International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB). J Int Soc Sports Nutr. 2025;22(1):2434734. doi:10.1080/15502783.2024.2434734

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#HMB #sarcopenia #sarcopeniaprevention