How to Improve Your Vitality & Heal From Disease | Dr. Mark Hyman

Andrew Huberman

Apr 14, 2025

Episode description

My guest is Dr. Mark Hyman, M.D., a physician and world leader in the field of functional medicine. We discuss a systems-based framework for diagnosing and treating the root causes of disease, rather than simply managing symptoms. We also cover cutting-edge health and longevity tools such as peptides, NAD/NMN, exosomes, proactive blood testing and cancer screening, as well as nutrition, supplementation, detoxification, and strategies for addressing specific diseases and health challenges. This discussion will benefit anyone seeking to improve their vitality or combat specific health concerns.

Read the episode show notes: https://go.hubermanlab.com/iKSCqnh

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*Dr. Mark Hyman*
Website: https://drhyman.com
UltraWellness Center: https://www.ultrawellnesscenter.com
Books: https://drhyman.com/pages/about-dr-hyman
Newsletter: https://drhyman.com/pages/longevity
Podcast: https://drhyman.com/blogs/content/tagged/podcast
Function Health: https://www.functionhealth.com
Facebook: https://www.facebook.com/drmarkhyman
Instagram: https://www.instagram.com/drmarkhyman
YouTube: https://www.youtube.com/user/ultrawellness
X: https://x.com/drmarkhyman
TikTok: https://www.tiktok.com/@drmarkhyman
Threads: https://www.threads.net/@drmarkhyman
LinkedIn: https://www.linkedin.com/in/drhyman

*Timestamps*
00:00:00 Dr. Mark Hyman
00:01:48 Functional Medicine, Chronic Fatigue Syndrome, Mercury; Systems Medicine
00:08:51 Metabolic Psychiatry; Medicine, Creating Health vs Treating Disease
00:12:19 Sponsors: Joovv & Eight Sleep
00:15:06 Wholistic View of Body, Root Causes
00:19:48 Medicine & Research; “Exposome”, Impediments & Ingredients for Health, Whole Foods
00:26:30 Seed Oils, Starch & Sugar, Ultra-Processed Foods; Obesity Rise
00:36:27 Sponsors: Function & ROKA
00:40:05 Tool: Ingredients for Health, Personalization; Multimodal Approach
00:46:25 Essential Supplements, Omega-3s, Vitamin D3, Multivitamin, Iodine, Methylated B12
00:56:54 Supplements & Traditional Medicine; Limited Budget & Nutrition
01:02:54 Air, Tool: Air Filters; Tap Water Filter; Tool: Health, Expense & Whole Foods
01:09:03 Food Industrialization, Processed Foods
01:14:23 Sponsor: AG1
01:16:18 Declining American Health & Nutrition, Politics, MAHA
01:26:03 Toxins, Food Additives, Generally Recognized As Safe (GRAS)
01:29:25 SNAP Program & Soda, Food Industry & Lobbying
01:36:58 Big Food, Company Consolidation, Nutrition Labels
01:44:21 GLP-1 Agonists, Doses, Risks; Food as Medicine, Ketogenic Diet
01:51:29 Cancer, Diets & Alcohol
01:54:03 Blood Markers, ApoB, Cholesterol, Tool: Test Don’t Guess, Individualization
02:02:54 Mercury; Tool: Detoxification, Sulforaphane, N-Acetylcysteine (NAC)
02:04:56 Endocrine Disrupting Chemicals, Fertility, Tool: Hormone Panels; Heavy Metals
02:11:36 Upregulate Detox Pathways, Gut Cleanse, Tools: Cilantro Juice, Fiber
02:17:08 Peptides, PT-141 (Vyleesi), BPC-157, Thymosin Alpha-1; Risks, Cycling
02:22:03 Cancer Screening, Data & Personalized Health; Alzheimer’s Disease
02:30:45 Longevity Switches, NAD, NMN; Exosomes, Stem Cells
02:39:50 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

#HubermanLab #Science #Health

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Mindsip insights from this episode:

Juice cilantro daily to detox heavy metals

Juicing a couple of bunches of cilantro every day is a simple hack that can help the body get rid of heavy metals.

#detox

Identify disruptions and essential ingredients for health in functional medicine

Functional medicine is based on answering two simple questions: what is interrupting your normal function, and what essential ingredients for health are you missing?.

#functional-medicine

Identify saturated fat and refined starch as dietary villains

The combination of saturated fat and refined starch is what's truly killing us, not necessarily fat or starches in isolation.

#nutrition

#saturated-fat

Incorporate omega-3, vitamin D3, and multivitamins for optimal health

Dr. Hyman believes most people should take omega-3 fats (1-2 grams of EPA/DHA), 2000-4000 IU of vitamin D3, and a good multivitamin with bioavailable forms of nutrients.

#omega-3

#supplement

Prioritize exposome over genome for health predictions

What your genes are exposed to throughout life, your 'exposome', is far more predictive of your health than your genome itself.

#environment

#genetics

Challenge sugary soda inclusion in SNAP for low-income families

A representative for the American Heart Association argued against removing sugary soda from the government-funded SNAP program for low-income families.

#nutrition

Monitor cholesterol levels on ketogenic diet for lean mass hyper-responders

A group known as 'lean mass hyper-responders' can experience a dramatic negative spike in cholesterol when following a ketogenic diet, unlike overweight individuals.

#cholesterol

#keto

Combine GLP-1 drugs with nutrition and strength training guidance

It should be illegal to prescribe GLP-1 agonists like Ozempic unless they are combined with nutrition and strength training guidance to prevent muscle loss.