I read all [18] NMN Human Studies – 4 Key Findings
Brad Stanfield
May 26, 2024
Episode description
I read all 18 human studies of NMN supplements to figure out if there are any proven benefits. This took many hours of work, but it was so worth it because I found 4 key takeaways
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Reference List
NMN Studies
Study 1: https://pubmed.ncbi.nlm.nih.gov/31685720/
Study 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550608/
Study 3: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265078/
Study 4: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877443/
Study 5: https://www.frontiersin.org/articles/10.3389/fnut.2022.868640/full
Study 6: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261366/
Study 7: https://www.toukastress.jp/webj/article/2022/GS22-16.pdf
Study 8: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400576/
Study 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534732/
Study 10: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735188/
Study 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158788/
Study 12: https://pubmed.ncbi.nlm.nih.gov/35182418/
Study 13: https://pubmed.ncbi.nlm.nih.gov/36443648/
Study 14: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935856/
Study 15: https://pubmed.ncbi.nlm.nih.gov/36740954/
Study 16: https://pubmed.ncbi.nlm.nih.gov/37344088/
Study 17: https://onlinelibrary.wiley.com/doi/10.1111/acel.13965
Study 18: https://www.nature.com/articles/s41392-023-01577-3
Mice:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/
https://onlinelibrary.wiley.com/doi/10.1111/acel.13328
https://academic.oup.com/innovateage/article/7/Supplement_1/1077/7490297
https://pubs.rsc.org/en/content/articlehtml/2024/fo/d3fo05221d
Glucosamine & Chondroitin
https://pubmed.ncbi.nlm.nih.gov/16495392/
https://www.uptodate.com/contents/management-of-knee-osteoarthritis
Other papers:
https://pubmed.ncbi.nlm.nih.gov/31710095/
https://www.nature.com/articles/s43587-022-00174-3
https://www.sciencedirect.com/science/article/pii/S0735109718345601?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345839/
https://pubmed.ncbi.nlm.nih.gov/38374343/
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.
Mindsip insights from this episode:
Reevaluate NMN supplements for muscle NAD effectiveness
Despite increasing NAD levels in the blood, the only human study that took muscle biopsies found that NMN supplements did not increase NAD content in the muscle.
Reject NR for lifespan extension based on rigorous mouse study
The most rigorous mouse research program, the Interventions Testing Program, found that NR (a molecule very similar to NMN) did not extend lifespan.
Limit Vitamin B3 intake to 50mg for safety
Due to safety concerns, the speaker limits his own Vitamin B3 intake to 50mg, which is far lower than the 1000mg dose in typical NMN supplements.
Limit Vitamin B3 intake to reduce blood vessel inflammation
A 2024 study suggests that excessive metabolites from all forms of Vitamin B3, including NMN, may worsen blood vessel inflammation.
Avoid high-dose NMN to reduce mortality risk
A meta-analysis found that high doses of niacin (1-3 grams), which NMN is converted into by the gut, increased mortality rates by 10%.
Critically evaluate NMN study results for insulin sensitivity
One NMN study claimed a benefit for insulin sensitivity, but this was only because the placebo group's health mysteriously worsened by 30% in just 60 days.
Maintain muscle NAD levels through regular exercise
A 2022 human study showed that older adults who exercise have muscle NAD levels similar to younger adults, suggesting exercise alone can maintain them.
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