I read all [18] NMN Human Studies – 4 Key Findings
Brad Stanfield
May 26, 2024
Mindsip insights from this episode:
Reevaluate NMN supplements for muscle NAD effectiveness
Despite increasing NAD levels in the blood, the only human study that took muscle biopsies found that NMN supplements did not increase NAD content in the muscle.
Reject NR for lifespan extension based on rigorous mouse study
The most rigorous mouse research program, the Interventions Testing Program, found that NR (a molecule very similar to NMN) did not extend lifespan.
Limit Vitamin B3 intake to 50mg for safety
Due to safety concerns, the speaker limits his own Vitamin B3 intake to 50mg, which is far lower than the 1000mg dose in typical NMN supplements.
Limit Vitamin B3 intake to reduce blood vessel inflammation
A 2024 study suggests that excessive metabolites from all forms of Vitamin B3, including NMN, may worsen blood vessel inflammation.
Avoid high-dose NMN to reduce mortality risk
A meta-analysis found that high doses of niacin (1-3 grams), which NMN is converted into by the gut, increased mortality rates by 10%.
Critically evaluate NMN study results for insulin sensitivity
One NMN study claimed a benefit for insulin sensitivity, but this was only because the placebo group's health mysteriously worsened by 30% in just 60 days.
Maintain muscle NAD levels through regular exercise
A 2022 human study showed that older adults who exercise have muscle NAD levels similar to younger adults, suggesting exercise alone can maintain them.
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