JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomyJOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6HIRE ME FOR CONSULTING: Consulting: https://bit.ly/3dmUl2H Created with BiorenderVideo linked at the End: https://youtu.be/M_ov7VHFzGI?si=qoS1VllYx5zBhBas0:00 - Introduction0:29 - 12,13 DiHOME and the Aged Heart3:15 - Raising 12, 13 DiHOME [Method 1]4:42 - Raising 12, 13 DiHOME [Method 2]5:19 - Consuming more 12, 13 DiHOME5:36 - One Complication7:22 - Main Points/Key Take-AwaysReferences[Study 526] Nirengi S, Buck B, Das D, et al. 12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII. Nat Commun. 2025;16(1):7088.Funding/Conflicts: Mixed Funding [Public: National Institutes of Health (NIH), including RO1AG060542, RO1DK133859-01A1, RO1HL171689, RO1HL165751, RO1HL156652, K01AG044437, RO1DK1122835, RO1DK099511, P30DK036836, DP1DK126199, and DP2EB028110, as well as several training grants, with additional support from a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; Non-Profit funding was provided by the American Heart Association through a Career Development Award and pre- and post-doctoral fellowships; Industry Funding: supplied by the Kao Research Council for the Study of Healthcare Science] // Potential direct Conflicts of Interest [Kristin I. Stanford and Daniel Gallego-Perez are co-inventors on a U.S. Patent related to the tissue nano-transfection technology used in the study, while the other authors declared no competing interests][A] Lynes MD, Leiria LO, Lundh M, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017;23(5):631-637. doi:10.1038/nm.4297[B] Stanford KI, Lynes MD, Takahashi H, et al. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018;27(5):1111-1120.e3. doi:10.1016/j.cmet.2018.03.020CRITIQUES, RULES, AND NOTESBe aware of the following rules before posting comments:- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES:If your comment is rude, you will be banned.If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.