
NAC: A Cancer causing Downfall?
Physionic
Nov 27, 2024
Mindsip insights from this episode:
Reconsider NAC supplementation due to potential cancer risk
A commentary in the journal Science raised concerns that N-acetylcysteine (NAC) supplementation might accelerate cancer growth, based on mouse model studies.
Limit NAC supplementation to those over 50 or with chronic conditions
The speaker suggests that NAC supplementation is likely only beneficial for people over the age of 50-60 or younger individuals with chronic conditions, not for the young and healthy.
Balance antioxidant intake for optimal cellular function
An overabundance of antioxidants like NAC can be detrimental because some oxidizing molecules are necessary for proper cellular function, making it a matter of balance.
Leverage NAC for improved DNA and mitochondrial health
Despite concerns from mouse models, human studies on NAC report positive outcomes, including improvements in metrics like DNA damage and mitochondrial health.
Investigate NAC's role in enhancing cell division in cancer studies
In mouse studies, NAC was found to increase the Ki67 protein marker, which indicates a higher rate of cell division, even in mice with existing cancer.
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