NAC: A Cancer causing Downfall?

Physionic

Nov 27, 2024

Episode description

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0:00 - Introduction
1:19 - NAC cancer causing link
4:29 - Harmful antioxidants
4:58 - My Take

References
[1] https://www.science.org/content/blog-post/n-acetyl-cysteine-warning-shot

[2] Breau M, Houssaini A, Lipskaia L, et al. The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice. JCI Insight. 2019;4(19):e127647. Published 2019 Oct 3. doi:10.1172/jci.insight.127647

[3] Schwalfenberg GK. N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks). J Nutr Metab. 2021;2021:9949453. Published 2021 Jun 9. doi:10.1155/2021/9949453

[4] Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022;14(5):1114. Published 2022 Mar 7. doi:10.3390/nu14051114

********CRITIQUES, RULES, AND NOTES********

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cancerrisk #supplements

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:19 - NAC cancer causing link
4:29 - Harmful antioxidants
4:58 - My Take

References
[1] https://www.science.org/content/blog-post/n-acetyl-cysteine-warning-shot

[2] Breau M, Houssaini A, Lipskaia L, et al. The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice. JCI Insight. 2019;4(19):e127647. Published 2019 Oct 3. doi:10.1172/jci.insight.127647

[3] Schwalfenberg GK. N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks). J Nutr Metab. 2021;2021:9949453. Published 2021 Jun 9. doi:10.1155/2021/9949453

[4] Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022;14(5):1114. Published 2022 Mar 7. doi:10.3390/nu14051114

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cancerrisk #supplements

Mindsip insights from this episode:

Reconsider NAC supplementation due to potential cancer risk

A commentary in the journal Science raised concerns that N-acetylcysteine (NAC) supplementation might accelerate cancer growth, based on mouse model studies.

Limit NAC supplementation to those over 50 or with chronic conditions

The speaker suggests that NAC supplementation is likely only beneficial for people over the age of 50-60 or younger individuals with chronic conditions, not for the young and healthy.

Balance antioxidant intake for optimal cellular function

An overabundance of antioxidants like NAC can be detrimental because some oxidizing molecules are necessary for proper cellular function, making it a matter of balance.

Leverage NAC for improved DNA and mitochondrial health

Despite concerns from mouse models, human studies on NAC report positive outcomes, including improvements in metrics like DNA damage and mitochondrial health.

Investigate NAC's role in enhancing cell division in cancer studies

In mouse studies, NAC was found to increase the Ki67 protein marker, which indicates a higher rate of cell division, even in mice with existing cancer.

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