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Thymus Improving TRIIM Study Cocktail: https://www.youtube.com/watch?v=rVoxfABoHh4&t=282s

0:00 - Introduction
0:29 - It’s Thymus Time
2:02 - Death’s Door is at the Thymus
6:12 - Preserving Thymic Health

References
[Study 726] Bernatz S, Prudente V, Pai S, et al. Thymic health consequences in adults. Nature. Published online 2026. doi:10.1038/s41586-026-10242-y

Funding/Conflict: Public Funding: From the study, support was reported from the NIH, the European Research Council, the Deutsche Forschungsgemeinschaft, the German Federal Ministry of Research, Technology and Space, and the Framingham Heart Study contract from the National Heart, Lung, and Blood Institute; Non-Profit Funding: From the study, additional support was reported from the Max Kade Foundation, Wilhelm-Sander Foundation, Lundbeck Foundation, Novo Nordisk Foundation, Savvaerksejer Jeppe Juhl og Hustru Ovita Juhl Research Stipend, CRUK, IASLC International Lung Cancer Foundation, Lung Cancer Research Foundation, Rosetrees Trust, and UKI NETs; Industry Funding: From the study, I did not see industry funding reported; Conflicts of Interest: From the study, M.J.-H. reported consulting, advisory, and speaker relationships with several companies and patent-related interests, and C.S. reported institutional support, grants, consulting fees, honoraria, leadership roles, stock interests, and multiple patents, while no other competing interests were listed in the cited disclosure section.

[Study 727] Spadaro O, Youm Y, Shchukina I, et al. Caloric restriction in humans reveals immunometabolic regulators of health span. Science. 2022;375(6581):671-677. doi:10.1126/science.abg7292
Funding/Conflict: Public Funding: From the study, support was reported from the NIH’s National Institute on Aging and National Institute of Arthritis and Musculoskeletal and Skin Diseases; Non-Profit Funding: From the study, support was also reported from the Glenn Foundation for Medical Research, Cure Alzheimer’s Fund, and the Aging Biology Foundation; Industry Funding: From the study, no industry funding was reported; Conflicts of Interest: From the study, the authors declared no competing interests.
[Study 728] Duggal NA, Pollock RD, Lazarus NR, Harridge S, Lord JM. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17(2):e12750. doi:10.1111/acel.12750

Funding/Conflict: Public Funding: From the study, no public funding was reported; Non-Profit Funding: From the study, the project was supported by the BUPA Foundation and the Glenn Foundation; Industry Funding: From the study, no industry funding was reported; Conflicts of Interest: From the study, the authors declared that they had no conflict of interest, and Janet M. Lord was supported by the NIHR Birmingham Biomedical Research Centre in Inflammation, University Hospital Birmingham, UK.

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