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0:00 - Introduction
0:28 - Pinky and the Shrinking Brain
2:44 - Visceral Why?
4:05 - Men, Women: Who Can Say?
5:50 - Give me 18 Months and I’ll have you Right!

References*
*Full Funding/Conflicts are provided in the free article (found in email list and Physionic Community Article Library)
[Study 781] Pachter D, Klein H, Kamer O, et al. Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife. Nature Communications. 2026. doi:10.1038/s41467-026-71141-4

[Study 782] Kanaya AM, Lindquist K, Harris TB, et al. Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) study. Archives of Neurology. 2009;66(3):329-335. doi:10.1001/archneurol.2008.570

[Study 783] Debette S, Beiser A, Hoffmann U, et al. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Annals of Neurology. 2010;68(2):136-144. doi:10.1002/ana.22062

[Study 784] Widya RL, Kroft LJM, Altmann-Schneider I, et al. Visceral adipose tissue is associated with microstructural brain tissue damage. Obesity. 2015;23:1092-1096. doi:10.1002/oby.21048

[Study 785] Lampe L, Zhang R, Beyer F, et al. Visceral obesity relates to deep white matter hyperintensities via inflammation. Annals of Neurology. 2019;85(2):194-203. doi:10.1002/ana.25396

[Study 786] Pachter D, Kaplan A, Tsaban G, et al. Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial. American Journal of Clinical Nutrition. 2024;120(5):1029-1036. doi:10.1016/j.ajcnut.2024.09.013

[Study 787] Gepner Y, Shelef I, Schwarzfuchs D, et al. Effect of distinct lifestyle interventions on mobilization of fat storage pools: CENTRAL magnetic resonance imaging randomized controlled trial. Circulation. 2018;137(11):1143-1157. doi:10.1161/CIRCULATIONAHA.117.030501

[Study 427] Kaplan A, Zelicha H, Yaskolka Meir A, et al. The effect of a high-polyphenol Mediterranean diet combined with physical activity on age-related brain atrophy: the DIRECT PLUS study. American Journal of Clinical Nutrition. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001

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