A 2018 head-to-head trial found the retinoid Adapalene is as effective as Tretinoin for reversing skin aging, making it preferable as it causes less irritation.

The amount of dermal collagen in the skin may be decreased by up to 75% with age due to the intrinsic, or chronological, aging process.

The chemical ingredient Bemotrizinol offers excellent UV protection but is a large molecule that doesn't get absorbed through the skin, combining the best of chemical and mineral sunscreens.

In perimenopausal women, hormone replacement therapy may delay skin thinning, reduce wrinkles, and improve wound healing.

A 2016 follow-up study showed that daily sunscreen use not only prevents but can also lead to the reversal of existing signs of skin aging.

A June 2023 study found that resistance exercise, more so than aerobic training, counteracts skin aging by improving skin elasticity and dermal thickness.

Three supplements with strong evidence for skin benefits are 10-15 grams of collagen peptides, 200 milligrams of hyaluronic acid, and non-mega doses of vitamin B3.