This Fatty Nutrient Reprograms Your Immune System (and Your Gut!)

Episode description

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0:00 - Introduction
1:44 - The Nutrient and your Immune System
7:53 - Is there greater Inflammation, though?
10:28 - How do we Apply this?
13:14 - Main Points

References
[Study 505] Schulthess J, Pandey S, Capitani M, et al. The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages. Immunity. 2019;50(2):432-445.e7. doi:10.1016/j.immuni.2018.12.018

Funding/Conflicts: Mixed Funding [Public: Wellcome Trust UK (095688/Z/11/Z), the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/I005609/1), and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre; Non-Profit: eona M. and Harry B. Helmsley Charitable Trust, the Kennedy Trust for Rheumatology Research, Cancer Research UK, and the Crohn’s & Colitis Foundation of America] // Potential Conflicts of Interest: H.H. Uhlig has received research support or consultancy fees from UCB Pharma, Eli Lilly, Boehringer Ingelheim, Pfizer, Celgene, AbbVie, and F. Powrie has received research support or consultancy fees from GSK, UCB Pharma, MedImmune, Janssen, Roche, and Eli Lilly

[A] Batista-Gonzalez A, Vidal R, Criollo A, Carreño LJ. New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages. Front Immunol. 2020;10:2993. Published 2020 Jan 10. doi:10.3389/fimmu.2019.02993

[B] Bacha AA, Suhail M, Awwad FA, Ismail EAA, Ahmad H. Role of dietary fiber and lifestyle modification in gut health and sleep quality [published correction appears in Front Nutr. 2024 May 14;11:1429023. doi: 10.3389/fnut.2024.1429023.] [published correction appears in Front Nutr. 2024 Sep 05;11:1429445. doi: 10.3389/fnut.2024.1429445.]. Front Nutr. 2024;11:1324793. Published 2024 Apr 3. doi:10.3389/fnut.2024.1324793

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#guthealth #nutritiontips

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:44 - The Nutrient and your Immune System
7:53 - Is there greater Inflammation, though?
10:28 - How do we Apply this?
13:14 - Main Points

References
[Study 505] Schulthess J, Pandey S, Capitani M, et al. The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages. Immunity. 2019;50(2):432-445.e7. doi:10.1016/j.immuni.2018.12.018

Funding/Conflicts: Mixed Funding [Public: Wellcome Trust UK (095688/Z/11/Z), the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/I005609/1), and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre; Non-Profit: eona M. and Harry B. Helmsley Charitable Trust, the Kennedy Trust for Rheumatology Research, Cancer Research UK, and the Crohn’s & Colitis Foundation of America] // Potential Conflicts of Interest: H.H. Uhlig has received research support or consultancy fees from UCB Pharma, Eli Lilly, Boehringer Ingelheim, Pfizer, Celgene, AbbVie, and F. Powrie has received research support or consultancy fees from GSK, UCB Pharma, MedImmune, Janssen, Roche, and Eli Lilly

[A] Batista-Gonzalez A, Vidal R, Criollo A, Carreño LJ. New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages. Front Immunol. 2020;10:2993. Published 2020 Jan 10. doi:10.3389/fimmu.2019.02993

[B] Bacha AA, Suhail M, Awwad FA, Ismail EAA, Ahmad H. Role of dietary fiber and lifestyle modification in gut health and sleep quality [published correction appears in Front Nutr. 2024 May 14;11:1429023. doi: 10.3389/fnut.2024.1429023.] [published correction appears in Front Nutr. 2024 Sep 05;11:1429445. doi: 10.3389/fnut.2024.1429445.]. Front Nutr. 2024;11:1324793. Published 2024 Apr 3. doi:10.3389/fnut.2024.1324793

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#guthealth #nutritiontips