Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway)
Dave Asprey
Jul 17, 2025
Mindsip insights from this episode:
Avoid arginine supplements with dysfunctional nitric oxide synthase
Supplementing with arginine when your nitric oxide synthase enzyme is dysfunctional can actually increase oxidative stress by generating superoxide radicals.
Combine nitric oxide lozenges with Cialis for enhanced effectiveness
Combining a nitric oxide lozenge with a low-dose PDE5 inhibitor like Cialis can turn non-responders into responders, making the drug effective.
Normalize blood pressure with fluoride-free prebiotic toothpaste
Switching to a fluoride-free, prebiotic toothpaste like Cardio Smile can normalize blood pressure in people whose hypertension is caused by oral dysbiosis.
Eliminate sugar to boost nitric oxide production
Sugar is the worst food for nitric oxide because it changes the oral and gut microbiome and causes enzyme dysfunction, completely shutting down production.
Avoid ineffective beet products for health benefits
Many commercial beet products are 'dead beets' with no active nitrate and are so ineffective they are used as placebos in clinical trials.
Address nitric oxide deficiency to combat insulin resistance
Insulin resistance is a symptom of nitric oxide deficiency, as NO is the crucial signaling molecule that tells cells to absorb glucose from the blood.
Avoid PPIs and statins to preserve nitric oxide production
Proton pump inhibitors (PPIs) and cholesterol-lowering statins are two classes of drugs that completely shut down systemic nitric oxide production.
Avoid antiseptic mouthwash to prevent blood pressure spikes
Using antiseptic mouthwash is like throwing an atomic bomb in your mouth, causing dysbiosis that raises blood pressure and negates the benefits of exercise.
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