Your Brain on Fish Oil - What Happens?

Physionic

May 30, 2025

Episode description

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0:00 - Introduction
1:03 - What happens to your Brain?
7:09 - Main Points

References
[Study 454] Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52. Published 2015 Apr 21. doi:10.3389/fnagi.2015.00052

Funding/Conflicts: Public Funding [European Union’s Horizon 2020 research and innovation program; Deutsche Forschungsgemeinschaft; German Federal Ministry of Education and Research] // No direct Conflicts of Interest

[Study 455] Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology. Pharmacol Rev. 2018;70(1):12–38. doi:10.1124/pr.117.014092

Funding/Conflicts: Public Funding [German Federal Ministry of Education and Research (BMBF)] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#fishoilbenefits

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:03 - What happens to your Brain?
7:09 - Main Points

References
[Study 454] Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52. Published 2015 Apr 21. doi:10.3389/fnagi.2015.00052

Funding/Conflicts: Public Funding [European Union’s Horizon 2020 research and innovation program; Deutsche Forschungsgemeinschaft; German Federal Ministry of Education and Research] // No direct Conflicts of Interest

[Study 455] Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology. Pharmacol Rev. 2018;70(1):12–38. doi:10.1124/pr.117.014092

Funding/Conflicts: Public Funding [German Federal Ministry of Education and Research (BMBF)] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#fishoilbenefits

Mindsip insights from this episode:

Calm brain's immune cells to promote healing

Efoxes bind to the brain's immune cells, called microglia, convincing them to switch from an inflammatory 'attack' phase to a 'clean and repair' phase.

Activate PPAR gamma to combat inflammation

Activated by Omega-3s, the protein PPAR gamma 'bullies' the pro-inflammatory pathway NF kappa B by stealing its activators and physically blocking it from inflammatory genes.

Tag proteins with omega-3s to combat inflammation

Omega-3s cause a tag to be attached to the PPAR gamma protein, allowing it to pick up 'hitchhikers' that help block inflammatory genes inside the cell's nucleus.

Enhance neurotransmitter efficiency with omega-3s

Omega-3s increase synapsin proteins, which create a larger reserve pool of vesicles packed with neurotransmitters, improving the efficiency of brain cell communication.

Transform omega-3s into anti-inflammatory Efoxes for better health

When enzymes in your brain interact with Omega-3s, they convert them into unique anti-inflammatory molecules called Efoxes.

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