Your Brain on Fish Oil - What Happens?

Physionic

May 30, 2025

Episode description

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0:00 - Introduction
1:03 - What happens to your Brain?
7:09 - Main Points

References
[Study 454] Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52. Published 2015 Apr 21. doi:10.3389/fnagi.2015.00052

Funding/Conflicts: Public Funding [European Union’s Horizon 2020 research and innovation program; Deutsche Forschungsgemeinschaft; German Federal Ministry of Education and Research] // No direct Conflicts of Interest

[Study 455] Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology. Pharmacol Rev. 2018;70(1):12–38. doi:10.1124/pr.117.014092

Funding/Conflicts: Public Funding [German Federal Ministry of Education and Research (BMBF)] // No direct Conflicts of Interest

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#fishoilbenefits

Mindsip insights from this episode:

Calm brain's immune cells to promote healing

Efoxes bind to the brain's immune cells, called microglia, convincing them to switch from an inflammatory 'attack' phase to a 'clean and repair' phase.

Activate PPAR gamma to combat inflammation

Activated by Omega-3s, the protein PPAR gamma 'bullies' the pro-inflammatory pathway NF kappa B by stealing its activators and physically blocking it from inflammatory genes.

Tag proteins with omega-3s to combat inflammation

Omega-3s cause a tag to be attached to the PPAR gamma protein, allowing it to pick up 'hitchhikers' that help block inflammatory genes inside the cell's nucleus.

Enhance neurotransmitter efficiency with omega-3s

Omega-3s increase synapsin proteins, which create a larger reserve pool of vesicles packed with neurotransmitters, improving the efficiency of brain cell communication.

Transform omega-3s into anti-inflammatory Efoxes for better health

When enzymes in your brain interact with Omega-3s, they convert them into unique anti-inflammatory molecules called Efoxes.

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