Your Kidneys Die when your Mitochondria Leak - Repair Both doing these 4 Things!

Physionic

Sep 15, 2025

Episode description

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0:00 - Introduction
0:13 - TFAM and Leaking Kidneys
4:59 - 4 Ways to Support TFAM
7:45 - Main Points

Next Video on Kidney Health: https://youtu.be/o8h5JK9I4FY?si=Ivzd6RskttDZ3zUf

References
[Study 517] Chung KW, Dhillon P, Huang S, et al. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metab. 2019;30:784-799. doi:10.1016/j.cmet.2019.08.003.

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#kidneyhealth #kidneydisease

Mindsip insights from this episode:

Address leaking mitochondria to protect kidney health

A lack of the mitochondrial protein TFAM can cause mitochondrial DNA to leak out, triggering immune cell invasion, cysts, and kidney cell death.

#kidney

#mitochondria

Balance sodium and potassium intake for kidney health

Achieving a proper balance between sodium and potassium intake, often by increasing potassium, can have a direct and powerful positive impact on the kidneys.

#kidney

#potassium

Utilize resveratrol to enhance kidney function and TFAM levels

The controversial supplement resveratrol has been shown in human studies to improve kidney function and may increase TFAM, especially in people with high blood sugar.

#kidney

#supplement

Manage high blood pressure to protect kidney function

High blood pressure is associated with reduced levels of the protective mitochondrial protein TFAM, directly harming kidney function and health.

#blood-pressure

#mitochondria

Target STING pathway to protect kidney cells from inflammation

Leaked mitochondrial DNA is detected by a protein called cGAS, which activates an inflammatory cascade known as the STING pathway, harming kidney cells.