#365 ‒ Training for longevity: A roundtable on building strength, preventing injury, meeting protein needs, guidance for women and youth athletes, and more | Gabrielle Lyon, Mike Boyle, Jeff Cavaliere

Peter Attia

Sep 22, 2025

Episode description

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In this special episode of The Drive, Peter hosts a strength and conditioning roundtable with three experts in the field—Gabrielle Lyon, Jeff Cavaliere, and Mike Boyle. Together they explore why maintaining muscle mass, strength, and power is essential for healthspan and longevity, and examine how resistance training supports metabolic resilience and injury prevention across the lifespan. The conversation covers practical strategies for getting started and staying consistent, the importance of a protein-centered diet tailored to age and activity level, and approaches to resistance training for peri- and post-menopausal women—including tendon care and optimal programming. They debate single-leg training versus heavy bilateral lifts, share knee-friendly lower-body options, and highlight exercises that belong in the “graveyard” due to poor risk-reward ratios. Finally, the group discusses youth sports specialization, emphasizing the long-term value of variety for developing lifelong athletes.

We discuss:

  • Personal career journeys and philosophies of each guest that shaped their approaches to strength, conditioning, and lifelong health [3:30];

  • Why so few people engage in resistance training despite its proven health benefits [8:30];

  • Mike’s low-stress, high-consistency method for training beginners to resistance training [18:45];

  • How resistance training enhances metabolic health and body composition even in lean, highly active endurance athletes [25:30];

  • The dominant role of nutrition in shaping physique and achieving low body fat, the synergistic effect of resistance training, and the unrealistic expectations about muscle growth and fat loss [28:30];

  • Why Jeff advocates for five meals a day, and why meal timing matters less than overall protein intake and caloric consistency [38:00];

  • Optimizing protein for every stage of life: quality, quantity, and guidelines for diverse diets and body types [44:15];

  • The advantages of unilateral lower-body training over heavy bilateral lifts: impact on strength, athleticism, recovery, and functional movement [51:45];

  • Rethinking heavy squats and deadlifts: risk-reward, aging bodies, an

Episode description

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

In this special episode of The Drive, Peter hosts a strength and conditioning roundtable with three experts in the field—Gabrielle Lyon, Jeff Cavaliere, and Mike Boyle. Together they explore why maintaining muscle mass, strength, and power is essential for healthspan and longevity, and examine how resistance training supports metabolic resilience and injury prevention across the lifespan. The conversation covers practical strategies for getting started and staying consistent, the importance of a protein-centered diet tailored to age and activity level, and approaches to resistance training for peri- and post-menopausal women—including tendon care and optimal programming. They debate single-leg training versus heavy bilateral lifts, share knee-friendly lower-body options, and highlight exercises that belong in the “graveyard” due to poor risk-reward ratios. Finally, the group discusses youth sports specialization, emphasizing the long-term value of variety for developing lifelong athletes.

We discuss:

  • Personal career journeys and philosophies of each guest that shaped their approaches to strength, conditioning, and lifelong health [3:30];

  • Why so few people engage in resistance training despite its proven health benefits [8:30];

  • Mike’s low-stress, high-consistency method for training beginners to resistance training [18:45];

  • How resistance training enhances metabolic health and body composition even in lean, highly active endurance athletes [25:30];

  • The dominant role of nutrition in shaping physique and achieving low body fat, the synergistic effect of resistance training, and the unrealistic expectations about muscle growth and fat loss [28:30];

  • Why Jeff advocates for five meals a day, and why meal timing matters less than overall protein intake and caloric consistency [38:00];

  • Optimizing protein for every stage of life: quality, quantity, and guidelines for diverse diets and body types [44:15];

  • The advantages of unilateral lower-body training over heavy bilateral lifts: impact on strength, athleticism, recovery, and functional movement [51:45];

  • Rethinking heavy squats and deadlifts: risk-reward, aging bodies, an

Mindsip insights from this episode:

Prioritize intramuscular fat for metabolic health assessment

The future of metabolic health assessment will likely focus less on overall body fat percentage and more on intramuscular adipose tissue (IMAT), the fat stored inside your muscles.

Consume at least 100g of protein daily for optimal health

Regardless of sex, the minimum amount of protein you should consume daily for health is 100 grams, which is significantly higher than the standard RDA.

Encourage kids to sample multiple sports for athletic development

Forcing kids into early, single-sport specialization is one of the worst things for their long-term athletic development; sampling multiple sports is key.

Swap barbell back squats for safer unilateral exercises

Most adults should swap risky bilateral lifts like barbell back squats and deadlifts for safer, more effective unilateral work like split squats and reverse lunges.

Train balance with eyes closed to enhance proprioception

To truly train for fall prevention as you age, you must practice balance exercises with your eyes closed, as this removes visual feedback and improves proprioception.

Perfect reverse lunge by widening your stance

Make the reverse lunge a pure strength exercise, not a balance challenge, by stepping not just back but also slightly out to widen your stance.

Build effective routine around 36-minute lift

An effective, hour-long training session for an adult can be built around a core 36-minute lift, making a consistent routine more achievable.

Eliminate risky exercises from your routine

Classic exercises like unsupported chest flies, Cuban presses, and upright rows may carry more risk than reward and belong in an "exercise graveyard.".

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© Mindsip 2025 – Made with ❤ in Vilnius