4 Experts on How to Build Muscle

Dave Asprey

Jul 18, 2024

Episode description

In this special episode of The Human Upgrade, you will gain insights from four fitness and health experts on understanding muscle, how to grow muscle, exercise effectively, and recover properly. 

Dr. Gabrielle Lyon, a functional medicine physician, emphasizes the critical role of skeletal muscle as an organ of longevity. She explains how muscle health impacts overall well-being and offers strategies to prevent age-related muscle loss. 

John Jaquish, the inventor of the X3 bar, discusses the benefits of variable resistance training. He shares his expertise on progressive overload and how data-driven training can enhance muscle growth and performance. 

Tony Horton, the creator of P90X, introduces the concept of muscle confusion. He explains how varying workout routines can prevent plateaus, reduce injuries, and keep your fitness journey exciting and effective. 

Magnus Lygdbäck, a celebrity trainer, provides tips on optimizing performance and recovery. He highlights the importance of structured habits, balanced nutrition, and recovery techniques like ice baths and isometric exercises to sustain high performance. 

Tune in to this episode to learn practical tips and expert advice on building muscle, improving exercise routines, and optimizing recovery for long-term health and fitness.  



CHECK OUT THE FULL EPISODES NOW! 

Dr. Gabrielle Lyon: https://youtu.be/X3hkW0afys0  

John Jaquish: https://youtu.be/6efQiP_rCLM  

Tony Horton: https://youtu.be/BRSvTx8Ank4  

Magnus Lygdbäck: https://youtu.be/9x3fvChVwyo  



Timestamps: 

00:00:00 — Opening 

00:00:10 — Dr. Gabrielle Lyon on Skeletal Muscle Health 

00:02:32 — Aging and Muscle 

00:06:03 — Measuring Muscle Quality 

00:09:15 — Genetic Potential 

00:20:41 — John Jaquish on Variable Resistance Training 

00:24:32 — Progressive Overload 

00:27:37 — Neurological Adaptation 

00:31:47 — Data-Driven Training 

00:34:39 — One Meal a Day and Protein 

00:44:15 — Tony Horton on Muscle Confusion 

00:47:45 — Using Bands for Resistance 

00:50:16 — Continuous Training 

00:52:03 — Balancing Rest and Work 

00:54:27 — Magnus Lygdbäck on Optimizing Performance 

00:57:15 — Nutrition vs. Training 

01:00:15 — Avoiding Perfectionism 

01:02:48 — Pre-Performance Training 

01:05:59 — Blood Flow Restriction 



 Sponsors: 

  • Calroy | Head over to

Episode description

In this special episode of The Human Upgrade, you will gain insights from four fitness and health experts on understanding muscle, how to grow muscle, exercise effectively, and recover properly. 

Dr. Gabrielle Lyon, a functional medicine physician, emphasizes the critical role of skeletal muscle as an organ of longevity. She explains how muscle health impacts overall well-being and offers strategies to prevent age-related muscle loss. 

John Jaquish, the inventor of the X3 bar, discusses the benefits of variable resistance training. He shares his expertise on progressive overload and how data-driven training can enhance muscle growth and performance. 

Tony Horton, the creator of P90X, introduces the concept of muscle confusion. He explains how varying workout routines can prevent plateaus, reduce injuries, and keep your fitness journey exciting and effective. 

Magnus Lygdbäck, a celebrity trainer, provides tips on optimizing performance and recovery. He highlights the importance of structured habits, balanced nutrition, and recovery techniques like ice baths and isometric exercises to sustain high performance. 

Tune in to this episode to learn practical tips and expert advice on building muscle, improving exercise routines, and optimizing recovery for long-term health and fitness.  



CHECK OUT THE FULL EPISODES NOW! 

Dr. Gabrielle Lyon: https://youtu.be/X3hkW0afys0  

John Jaquish: https://youtu.be/6efQiP_rCLM  

Tony Horton: https://youtu.be/BRSvTx8Ank4  

Magnus Lygdbäck: https://youtu.be/9x3fvChVwyo  



Timestamps: 

00:00:00 — Opening 

00:00:10 — Dr. Gabrielle Lyon on Skeletal Muscle Health 

00:02:32 — Aging and Muscle 

00:06:03 — Measuring Muscle Quality 

00:09:15 — Genetic Potential 

00:20:41 — John Jaquish on Variable Resistance Training 

00:24:32 — Progressive Overload 

00:27:37 — Neurological Adaptation 

00:31:47 — Data-Driven Training 

00:34:39 — One Meal a Day and Protein 

00:44:15 — Tony Horton on Muscle Confusion 

00:47:45 — Using Bands for Resistance 

00:50:16 — Continuous Training 

00:52:03 — Balancing Rest and Work 

00:54:27 — Magnus Lygdbäck on Optimizing Performance 

00:57:15 — Nutrition vs. Training 

01:00:15 — Avoiding Perfectionism 

01:02:48 — Pre-Performance Training 

01:05:59 — Blood Flow Restriction 



 Sponsors: 

  • Calroy | Head over to

Mindsip insights from this episode:

Implement weekly training protocol with one set to failure for strength

A novel training approach involves doing just one set to absolute failure per exercise once a week for strength, and lighter volume work on other days to promote blood flow and size.

Address skeletal muscle to prevent major diseases of aging

Many diseases of aging, like Alzheimer's and type 2 diabetes, are not end-state diseases but are actually diseases of skeletal muscle first.

Understand limitations of DEXA scans in measuring muscle mass

The DEXA scan, often considered the gold standard for body composition, does not directly measure skeletal muscle mass or quality, but rather provides an estimation of lean body mass.

Preserve muscle as body armor against sickness and injury

An individual can lose about two pounds of skeletal muscle in just five to seven days of immobility, highlighting the importance of muscle as "body armor" against sickness or injury.

Maximize neurological efficiency for strength without bulk

The incredible strength of smaller individuals like Shaolin monks is primarily due to neurological efficiency, which is the ability to recruit a higher percentage of muscle fibers.

Debunk protein absorption limits to maximize muscle building

A recent study suggests there is no upper limit for protein absorption per meal; the body simply uses it to build muscle for a longer period, debunking the old 50-gram rule.

Aim for 17 out of 20 meals to sustain dietary consistency

To maintain dietary consistency without burnout, aim for 17 out of 20 meals to be on point, allowing for three "off" meals to enjoy life and avoid the failure cycle of perfectionism.

Reprogram posture with isometric exercises for better airflow

You can reprogram your postural muscles and improve airflow by performing isometric exercises, like pushing your head back against a surface, for more than six seconds.

Train muscles to prevent insulin resistance

Skeletal muscle that is not trained becomes like a marbled steak, infiltrated with fat, which is a major cause of insulin resistance.

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© Mindsip 2025 – Made with ❤ in Vilnius