A Toxic Protein Is Clogging Your Arteries—Protect your Kidneys to Stop it!

Physionic

Aug 21, 2025

Episode description

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0:00 - Introduction
0:23 - The Toxic Protein - Progerin
5:44 - A Quick Summary
6:12 - Preventing this Toxicity - How?
9:13 - Main Points

References
[Study 507] Revêchon G, Witasp A, Viceconte N, et al. Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease. Nat Aging. 2025;5(6):1046-1062. doi:10.1038/s43587-025-00882-6

Funding/Conflicts: Mixed Funding [Public: NIH grants: AG025302, HL089441, AR056849, GM094503, CA122105, AG031321 / Non-Profit Funding: Progeria Research Foundation (PRF); Ellison Medical Foundation; American Heart Association; Glenn Foundation for Medical Research] // No direct Conflicts of Interest]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:23 - The Toxic Protein - Progerin
5:44 - A Quick Summary
6:12 - Preventing this Toxicity - How?
9:13 - Main Points

References
[Study 507] Revêchon G, Witasp A, Viceconte N, et al. Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease. Nat Aging. 2025;5(6):1046-1062. doi:10.1038/s43587-025-00882-6

Funding/Conflicts: Mixed Funding [Public: NIH grants: AG025302, HL089441, AR056849, GM094503, CA122105, AG031321 / Non-Profit Funding: Progeria Research Foundation (PRF); Ellison Medical Foundation; American Heart Association; Glenn Foundation for Medical Research] // No direct Conflicts of Interest]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Choose Cystatin C test for accurate kidney health assessment in athletes

For those who exercise or supplement with creatine, a Cystatin C test is a more accurate marker of kidney health than standard tests like serum creatinine.

Limit NSAID use to protect kidney health

Overconsumption of non-steroidal anti-inflammatory drugs (NSAIDs) is a prime example of a nephrotoxin that can directly harm your kidneys over time.

Combat Progerin accumulation to protect arterial health

The accumulation of Progerin causes arterial cells to malfunction by abnormally multiplying, migrating away from their post in the artery wall, and ultimately dying.

Address Progerin accumulation to protect arterial health

The toxic protein Progerin, once thought exclusive to a rare genetic disease, can accumulate and damage arteries in anyone with declining kidney function.

Address kidney function to prevent artery cell mutation

Poor kidney function allows 'uremic toxins' to build up, which physically damage the genes of arterial cells, causing them to produce the toxic protein Progerin.

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