C15 Fats: What No One is Telling You [7 Studies Later]

Physionic

Sep 18, 2024

Episode description

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REFERENCES
[Study 334] Venn-Watson S, Schork NJ. Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients. 2023;15(21):4607. Published 2023 Oct 30. doi:10.3390/nu15214607

[Study 335] Venn-Watson SK, Butterworth CN. Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PLoS One. 2022;17(5):e0268778. Published 2022 May 26. doi:10.1371/journal.pone.0268778

[Study 336] Robinson MK, Lee E, Ugalde-Nicalo PA, et al. Pentadecanoic Acid Supplementation in Young Adults with Overweight and Obesity: A Randomized Controlled Trial. J Nutr. Published online July 26, 2024. doi:10.1016/j.tjnut.2024.07.030

[Study 337] Jenkins B, West JA, Koulman A. A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease. Molecules. 2015;20(2):2425-2444. Published 2015 Jan 30. doi:10.3390/molecules20022425

[Study 338] Venn-Watson S, Lumpkin R, Dennis EA. Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Sci Rep. 2020;10(1):8161. Published 2020 May 18. doi:10.1038/s41598-020-64960-y

[Study 339] Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutrients. 2018;10(11):1646. Published 2018 Nov 3. doi:10.3390/nu10111646

[Study 340] Santaren ID, Watkins SM, Liese AD, et al. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. Am J Clin Nutr. 2014;100(6):1532-1540. doi:10.3945/ajcn.114.092544

[Study 341] Chooi YC, Zhang QA, Magkos F, et al. Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial. Am J Clin Nutr. 2024;119(3):788-799. doi:10.1016/j.ajcnut.2023.11.013

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H


Created with Biorender

REFERENCES
[Study 334] Venn-Watson S, Schork NJ. Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients. 2023;15(21):4607. Published 2023 Oct 30. doi:10.3390/nu15214607

[Study 335] Venn-Watson SK, Butterworth CN. Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PLoS One. 2022;17(5):e0268778. Published 2022 May 26. doi:10.1371/journal.pone.0268778

[Study 336] Robinson MK, Lee E, Ugalde-Nicalo PA, et al. Pentadecanoic Acid Supplementation in Young Adults with Overweight and Obesity: A Randomized Controlled Trial. J Nutr. Published online July 26, 2024. doi:10.1016/j.tjnut.2024.07.030

[Study 337] Jenkins B, West JA, Koulman A. A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease. Molecules. 2015;20(2):2425-2444. Published 2015 Jan 30. doi:10.3390/molecules20022425

[Study 338] Venn-Watson S, Lumpkin R, Dennis EA. Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Sci Rep. 2020;10(1):8161. Published 2020 May 18. doi:10.1038/s41598-020-64960-y

[Study 339] Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutrients. 2018;10(11):1646. Published 2018 Nov 3. doi:10.3390/nu10111646

[Study 340] Santaren ID, Watkins SM, Liese AD, et al. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. Am J Clin Nutr. 2014;100(6):1532-1540. doi:10.3945/ajcn.114.092544

[Study 341] Chooi YC, Zhang QA, Magkos F, et al. Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial. Am J Clin Nutr. 2024;119(3):788-799. doi:10.1016/j.ajcnut.2023.11.013

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Utilize C15 to enhance liver health

In one human study, participants who effectively absorbed C15 showed reductions in specific liver enzymes, indicating a likely improvement in liver health.

Differentiate C15 saturated fat from harmful varieties

Unlike other saturated fats, C15 is an odd-chain saturated fat that is not associated with negative outcomes like diabetes and heart disease.

Avoid C15 supplements; Mediterranean diet suffices for fatty liver

In a study on people with fatty liver disease, adding C15 supplements to a Mediterranean diet provided no additional benefits compared to the diet alone.

Recognize C15's limited impact on mitochondrial stress reduction

While cell studies show C15 can reduce mitochondrial stress (ROS), the effect is a relatively small 12-15% reduction, which is not a mind-blowing result.

Question validity of C15 research due to lack of vehicle control

Many of the cell studies supporting C15 failed to use a proper 'vehicle control,' a standard scientific method that casts doubt on the validity of the findings.

Critique C15 and rapamycin comparisons based on weak data

Comparisons showing C15 has similar effects to anti-aging drugs like rapamycin are based on weak data that only shows the direction of change without any actual values.

Avoid spending on C15 fat supplements due to weak evidence

Based on the current weak and conflicting evidence, the speaker strongly advises against spending money on C15 fat supplements.

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