Collagen: Joint Pain Relief or Pointless Supplement?

Physionic

Aug 18, 2025

Episode description

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*HEALTH AUTONOMY [COURSE]*
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Created with Biorender

0:00 - Introduction
1:28 - Collagen Absorption
3:13 - The Effects of Collagen
8:03 - Several Important Considerations...
10:58 - Main Points

References
[Study 366] Martínez-Puig D, Costa-Larrión E, Rubio-Rodríguez N, Gálvez-Martín P. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients. 2023;15(6):1332. Published 2023 Mar 8. doi:10.3390/nu15061332

Funding/Conflicts: None / Potential Conflicts of Interest [Researchers are employees of Industry, Bioiberica]

[Study 367] Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021;53(10):1493-1506. doi:10.1007/s00726-021-03072-x

Funding/Conflicts: Industry [Rousselot BVBA] / No other Conflicts of Interest

[Study 368] García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43(3):531-538. doi:10.1007/s00264-018-4211-5

Funding/Conflicts: Unknown Funding / No Potential Conflicts of Interest

[Study 495] Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, Vilchez-Cavazos F. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43(1):126-134. doi:10.55563/clinexprheumatol/kflfr5

Funding/Conflicts: No Funding / No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#collagen #arthritis #jointpainrelief

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:28 - Collagen Absorption
3:13 - The Effects of Collagen
8:03 - Several Important Considerations...
10:58 - Main Points

References
[Study 366] Martínez-Puig D, Costa-Larrión E, Rubio-Rodríguez N, Gálvez-Martín P. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients. 2023;15(6):1332. Published 2023 Mar 8. doi:10.3390/nu15061332

Funding/Conflicts: None / Potential Conflicts of Interest [Researchers are employees of Industry, Bioiberica]

[Study 367] Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021;53(10):1493-1506. doi:10.1007/s00726-021-03072-x

Funding/Conflicts: Industry [Rousselot BVBA] / No other Conflicts of Interest

[Study 368] García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43(3):531-538. doi:10.1007/s00264-018-4211-5

Funding/Conflicts: Unknown Funding / No Potential Conflicts of Interest

[Study 495] Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, Vilchez-Cavazos F. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43(1):126-134. doi:10.55563/clinexprheumatol/kflfr5

Funding/Conflicts: No Funding / No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#collagen #arthritis #jointpainrelief

Mindsip insights from this episode:

Question the effectiveness of collagen and exercise pairing

Despite suggestions that pairing collagen with exercise boosts its effects, the limited existing research on this combination is not impressive.

Compare collagen to other protein sources for accurate benefits assessment

A major flaw in current research is that collagen is only compared to a placebo, not other protein sources, so we don't know if the benefit is unique.

Stick to hydrolyzed collagen peptides for arthritis relief

Until more evidence emerges on other forms, the speaker recommends sticking to hydrolyzed collagen peptides for those with arthritis.

Utilize collagen peptides to boost your body's collagen production

Collagen peptides don't just supply building blocks, but act as bioactive signals that stimulate your cells to produce more of their own collagen.

Acknowledge mild benefits of collagen for joint health

While meta-analyses show collagen improves joint health, the effect is mild, representing less than a 10% improvement on the WOMAC score.

Question industry-funded research on collagen for joint health

A critical point to consider is that all of the current research on collagen for joint health is associated with the industry, which may introduce bias.

Utilize native collagen to teach immune tolerance in arthritis

For autoimmune arthritis, consumed native collagen may act as a distraction, teaching the immune system to tolerate the body's own collagen and reduce its attack on the joints.

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