
“Collagen Supplements are a Scam”
Physionic
Sep 26, 2025
Mindsip insights from this episode:
Set realistic expectations for collagen benefits on skin
Reasonable expectations for collagen are small to moderate improvements in skin, not a life-changing reversal of aging that turns back the clock by decades.
Compare collagen supplements with other proteins to reveal unique benefits
A critical weakness in current collagen research is the absence of studies comparing collagen supplements directly against other forms of protein to prove a unique benefit.
Rethink collagen supplements for skin improvement
When the meta-analysis isolated only the methodologically high-quality studies, they also revealed no significant effect of collagen supplements for improving skin.
Recognize funding bias in collagen research for informed decisions
In a new meta-analysis, studies not funded by supplement companies showed no significant effect of collagen on skin, while industry-funded studies showed significant improvements.
Leverage collagen's bioactive peptides to boost structural protein production
The argument for collagen is not that it provides building blocks, but that its absorbed di- and tripeptides are bioactive and signal cells to produce more structural proteins.
Understand subgroup analysis impact on study conclusions
The meta-analysis's negative conclusion is likely due to subgroup analysis reducing the number of studies so much that it loses the statistical power to detect a real effect.
Uncover positive effects of collagen supplementation in independent studies
Despite the meta-analysis's conclusion, a deeper look shows that six out of the seven independent, non-industry-funded studies actually found a positive effect from collagen supplementation.
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