Taking powerful antioxidant supplements like ALA can interfere with the beneficial oxidative stress signals from exercise that are necessary for muscles to adapt and grow stronger.

In a study on diabetic neuropathy, a 600mg dose of ALA reduced symptoms, but higher doses of 1200mg and 1800mg showed no additional benefits and increased side effects like nausea and vertigo.

A human study found that an antioxidant supplement cocktail which included ALA actually accelerated cognitive decline when compared to a placebo.

A Cochrane review showed that certain antioxidant supplements, specifically beta-carotene, vitamin E, and high doses of vitamin A, can actually increase death rates.

The bioavailability of alpha-lipoic acid from food is naturally optimized, as the body can regulate its absorption and utilization in a way that supplements cannot replicate.

If you are considering taking alpha-lipoic acid, it is crucial to choose a supplement that contains the R-isomer, as this is the natural and active form used by the body.

In a mouse study, researchers found that while ALA improved memory in aged mice, it also significantly shortened their lifespan.